Abstract
In a patient (BAR) affected by chronic active hepatitis we isolated a cryoglobulin constituted of polyclonal IgM (κ and λ) and a monoclonal IgG3 λ. The IgM represented the antibody of the cryoglobulin complex. This type of cryoglobulin, where the monoclonal component is the antigen and not the antibody, cannot be correctly classified using the nomenclature of Brouet et al. (1) currently in use. In this patient a two-year follow-up excluded any clinical signs of cryoglobulin toxicity. The immunochemical and clinical characterization of other cryoglobulins similar to BAR could establish a new homogeneous group.
| Original language | English |
|---|---|
| Pages (from-to) | 399-402 |
| Number of pages | 4 |
| Journal | Clinical and Experimental Rheumatology |
| Volume | 9 |
| Issue number | 4 |
| Publication status | Published - 1991 |
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ASJC Scopus subject areas
- Immunology
- Rheumatology
Cite this
Immunochemical characteristics of a particular cryoglobulin. A new cryoglobulin subgroup? / Bellotti, V.; Zorzoli, I.; Bossi, A.; Rancati, E.; Salvadeo, A.; Merlini, G.
In: Clinical and Experimental Rheumatology, Vol. 9, No. 4, 1991, p. 399-402.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunochemical characteristics of a particular cryoglobulin. A new cryoglobulin subgroup?
AU - Bellotti, V.
AU - Zorzoli, I.
AU - Bossi, A.
AU - Rancati, E.
AU - Salvadeo, A.
AU - Merlini, G.
PY - 1991
Y1 - 1991
N2 - In a patient (BAR) affected by chronic active hepatitis we isolated a cryoglobulin constituted of polyclonal IgM (κ and λ) and a monoclonal IgG3 λ. The IgM represented the antibody of the cryoglobulin complex. This type of cryoglobulin, where the monoclonal component is the antigen and not the antibody, cannot be correctly classified using the nomenclature of Brouet et al. (1) currently in use. In this patient a two-year follow-up excluded any clinical signs of cryoglobulin toxicity. The immunochemical and clinical characterization of other cryoglobulins similar to BAR could establish a new homogeneous group.
AB - In a patient (BAR) affected by chronic active hepatitis we isolated a cryoglobulin constituted of polyclonal IgM (κ and λ) and a monoclonal IgG3 λ. The IgM represented the antibody of the cryoglobulin complex. This type of cryoglobulin, where the monoclonal component is the antigen and not the antibody, cannot be correctly classified using the nomenclature of Brouet et al. (1) currently in use. In this patient a two-year follow-up excluded any clinical signs of cryoglobulin toxicity. The immunochemical and clinical characterization of other cryoglobulins similar to BAR could establish a new homogeneous group.
UR - http://www.scopus.com/inward/record.url?scp=0025848299&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025848299&partnerID=8YFLogxK
M3 - Article
C2 - 1934690
AN - SCOPUS:0025848299
VL - 9
SP - 399
EP - 402
JO - Clinical and Experimental Rheumatology
JF - Clinical and Experimental Rheumatology
SN - 0392-856X
IS - 4
ER -