Immunochemical characterization of the cryoglobulins: Pathophysiologic implications

G. Merlini, I. Zorzoli, E. Anesi, V. Perfetti, G. Marinone

Research output: Contribution to journalArticlepeer-review


Immunochemical study of the cryoglobulins has produced a classification of three main types which present clinical correlates. With the current standard immunofixation technique the vast majority of cryoglobulins are presently classified as type II. High-resolution immunoelectrophoretic techniques (immunoblotting and two-dimensional polyacrylamide gel electrophoresis) have helped to identify new sub-types whose clinical relevance is as yet undetermined. Nevertheless, these sensitive techniques could contribute to elucidate the various stages in the natural history of HCV-related cryoglobulins, from possible earlier HCV-antigen-driven polyclonal B cell proliferation, to autonomous monoclonal benign, to malignant B cell proliferation.

Original languageEnglish
JournalClinical and Experimental Rheumatology
Issue numberSUPPL. 13
Publication statusPublished - 1995


  • cryoglobulinemia
  • HCV
  • immunoblotting
  • immunofixation
  • two-dimensional polyacrylamide gel electrophoresis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology


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