Immunocytochemical analysis of contact Lens surface deposits in transmission electron microscopy

Piera Versura, Maria Cristina Maltarello, Roberto Caramazza, Renzo Laschi

Research output: Contribution to journalArticlepeer-review


We studied 8 soft contact lenses from asymptomatic wearers by means of an immuno-cytochemical method, in transmission electron microscopy. In particular, the presence of IgA, IgG, IgE, C1q complement fraction within the surface deposits was analyzed. All the lenses were found positive for the immunoglobulins and the C1q, being the tarsal side more heavily coated than the corneal one. IgA was the predominant Ig, followed by IgG, IgE, and C1q in this descending order. New, never worn lenses were found completely negative for any of the proteins under investigation. We conclude that the Igs come from the tear fluid and speculate about the C1q as a possible sign of involvement of the host immuno-defense mechanism against the prosthesis.

Original languageEnglish
Pages (from-to)277-286
Number of pages10
JournalCurrent Eye Research
Issue number3
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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