Immunocytochemical detection of factor XIII a-subunit in acute leukemia

Rosangela Invernizzi, Pasqualina De Fazio, Angela Maria Iannone, Luisa M. Zambelli, Maria Pia Rastaldi, Giovanbattista Ippoliti, Edoardo Ascari

Research output: Contribution to journalArticlepeer-review


Factor XIII (FXIII) is a plasma pro-transglutaminase consisting of A and B subunits in a tetrameric structure. A cellular form of FXIII consisting exclusively of A subunits exists in platelets and monocytes: monocyte FXIII may be involved in connective tissue organization. To evaluate the expression and diagnostic significance of FXIII A subunit (FXIIIA) in acute leukemia, we performed an immunocytochemical study (PAP technique) with rabbit antiserum against FXIIIA on leukemic blasts of 48 cases. FXIIIA was detected only in myelomonocytic (M4), monocytic (M5) and megakaryocytic (M7) cases: in M4 and M5 samples the amount of blast cytoplasmic FXIIIA was closely correlated with the expression of monocyte-specific antigenic and cytochemical markers. Our data show immunocytochemical detection of FXIIIA to be useful for acute leukemia characterization.

Original languageEnglish
Pages (from-to)829-836
Number of pages8
JournalLeukemia Research
Issue number8
Publication statusPublished - 1992


  • acute leukemia
  • Factor XIIIA
  • immunocytochemistry
  • monocytic cells

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology


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