Immunocytochemical study of nebulin in Duchenne muscular dystrophy

E. Bonilla, A. F. Miranda, A. Prelle, G. Salviati, R. Betto, M. Zeviani, E. A. Schon, S. Di Mauro, L. P. Rowland

Research output: Contribution to journalArticle

Abstract

We used antibodies to nebulin in immunocytochemical studies. In normal muscle, nebulin was localized at the I band. The protein was also present in most fibers from all 15 Duchenne muscular dystrophy (DMD) patients studied, including patients who seemed to lack nebulin in electrophoretic gels and patients who demonstrated deletions of DNA in the region of Xp21. These results conform to other evidence that nebulin is not the primarily affected gene product in DMD; it may be affected secondarily.

Original languageEnglish
Pages (from-to)1600-1603
Number of pages4
JournalNeurology
Volume38
Issue number10
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

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    Bonilla, E., Miranda, A. F., Prelle, A., Salviati, G., Betto, R., Zeviani, M., Schon, E. A., Di Mauro, S., & Rowland, L. P. (1988). Immunocytochemical study of nebulin in Duchenne muscular dystrophy. Neurology, 38(10), 1600-1603.