TY - JOUR
T1 - Immunocytochemistry of acute myeloid leukemias
T2 - an ultrastructural study by the immunogold method.
AU - Polli, N.
AU - Meroni, G.
AU - Soligo, D.
AU - Cattoretti, G.
AU - Maiolo, A. T.
AU - Lambertenghi-Deliliers, G.
PY - 1987/1
Y1 - 1987/1
N2 - Light microscopy morphology and cytochemistry, immunology, and ultrastructural morphology, cytochemistry and immunocytochemistry studies were performed in 18 cases of acute myeloid leukemia (8 M1, 1 M2, 7 M3 and 2 M4, according to the FAB classification). The aim of the investigation was to assess the value of electron microscopy, particularly the immunogold method, in the different FAB subclasses. Transmission electron microscopy with its more recent techniques of investigation was shown to have an important role in diagnosis of early myeloid (M0-M1) and mixed (M4) cases, where it was determinant in correlating ultrastructural morphology with cytochemistry and immunology and thus identifying the different cell populations. On the contrary, in cases in which the leukemic cells showed homogeneous features, light microscopy was adequate and sufficient for correct diagnosis.
AB - Light microscopy morphology and cytochemistry, immunology, and ultrastructural morphology, cytochemistry and immunocytochemistry studies were performed in 18 cases of acute myeloid leukemia (8 M1, 1 M2, 7 M3 and 2 M4, according to the FAB classification). The aim of the investigation was to assess the value of electron microscopy, particularly the immunogold method, in the different FAB subclasses. Transmission electron microscopy with its more recent techniques of investigation was shown to have an important role in diagnosis of early myeloid (M0-M1) and mixed (M4) cases, where it was determinant in correlating ultrastructural morphology with cytochemistry and immunology and thus identifying the different cell populations. On the contrary, in cases in which the leukemic cells showed homogeneous features, light microscopy was adequate and sufficient for correct diagnosis.
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M3 - Article
C2 - 3470529
AN - SCOPUS:0023080795
VL - 19
SP - 185
EP - 192
JO - Journal of Submicroscopic Cytology and Pathology
JF - Journal of Submicroscopic Cytology and Pathology
SN - 1122-9497
IS - 1
ER -