Immunocytological and mineralogical study of bronchoalveolar lavage in a group of subjects exposed to asbestos

Giuseppe Brunetti, M. Delmastro, R. Fonte, G. Moscato, A. Bossi, P. Baiardi, A. Massola, F. Meloni

Research output: Contribution to journalArticle

Abstract

Twenty-five subjects (24 males and 1 female, mean age 57.4 years) who have been exposed to asbestos underwent chest radiography, high resolution computed tomography (HRCT) of the chest, lung function tests and bronchoalveolar lavage (BAL) for evaluation of cell components (total cell count, percentages of macrophages, lymphocytes, neutrophil and eosinophil granulocytes and the lymphocyte subpopulations CD3+, CD4+, CD8+, CD19+ and HLADR+), soluble factors (IL-8, IL-10, IL-12 and MCP-1 in the supernatant) and concentration of asbestos fibre. The subjects were subdivided according to the degree of their exposure, to the concentration of asbestos fibres in the BAL and to chest X-ray findings using the I.L.O. classification (0/0pl, 0/1 and 1/0 and above). According to the exposure index, we showed statistically significant (p

Original languageEnglish
Pages (from-to)152-160
Number of pages9
JournalGiornale Italiano di Medicina del Lavoro ed Ergonomia
Volume25
Issue number2
Publication statusPublished - Apr 2003

Keywords

  • Asbestosis
  • Bronchoalveolar lavage
  • Cytokines

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Rehabilitation

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