Immunodeficiency in Down's syndrome: T-lymphocyte subset imbalance in trisomic children

G. R. Burgio, A. Lanzavecchia, R. Maccario, A. Vitiello, A. Plebani, A. G. Ugazio

Research output: Contribution to journalArticlepeer-review


In fourteen children with Down's syndrome, the percentage of circulating T-cells forming rosettes with sheep erythrocytes, either in the presence or in the absence of foetal calf serum, was significantly lower than in appropriately matched controls. In contrast, the percentage of T-cells forming rosettes with human erythrocytes was significantly higher in children with Down's syndrome than in controls. These data support the hypothesis that a defective T-cell maturation is an early integral feature of Down's syndrome.

Original languageEnglish
Pages (from-to)298-301
Number of pages4
JournalClinical and Experimental Immunology
Issue number2
Publication statusPublished - 1978

ASJC Scopus subject areas

  • Immunology


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