Immunodetection of proliferating cell nuclear antigen assesses the growth fraction and predicts malignancy in endocrine tumors of the pancreas

G. Pelosi, G. Zamboni, C. Doglioni, S. Rodella, E. Bresaola, C. Iacono, G. Serio, A. Iannucci, A. Scarpa

Research output: Contribution to journalArticle

Abstract

Thirty-five endocrine tumors of the pancreas, 17 functioning and 18 nonfunctioning, were immunohistochemically studied for the expression of proliferating cell nuclear antigen (PCNA) using 19A2 and PC10 monoclonal antibodies. The proportion of PCNA-reactive cells (PCNA index) ranged from 0.2 to 27% in functioning tumors and from 0.1% to 55% in nonfunctioning tumors. PCNA index showed a statistically significant correlation with mitotic and Ki67 indexes. The median values of PCNA index identified three groups of patients: group A (PCNA ≤ 2%), including 13 functioning and six nonfunctioning tumors; group B (PCNA between 2 and 5%), including three functioning and three nonfunctioning tumors; group C (PCNA > 5%), including one functioning and nine nonfunctioning tumors. All group A tumors were confined to the pancreas. In group B, the functioning tumors were limited to the pancreas, and the nonfunctioning tumors extended to extrapancreatic tissues. All group C patients had extrapancreatic extension of the disease. At follow-up, a PCNA index higher than 5% correlated to a decreased mean survival. Our data suggest that PCNA index is a reliable tool to assess the growth fraction, discern local from advanced diseases, and predict malignancy in pancreatic endocrine tumors.

Original languageEnglish
Pages (from-to)1215-1225
Number of pages11
JournalAmerican Journal of Surgical Pathology
Volume16
Issue number12
DOIs
Publication statusPublished - 1992

Keywords

  • Endocrine tumor
  • Growth fraction
  • Pancreas
  • Proliferating cell nuclear antigen
  • Tumor prognosis

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

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