Immunoelectron microscopy of different forms of glomerulonephritis in routine biopsy material

Ch Ihling, V. Olivieri, G. Banfi, B. Fogazzi, A. Edefonti, F. Gudat, M. J. Mihatsch

Research output: Contribution to journalArticlepeer-review

Abstract

Renal biospies were investigated of patients with IgA or membraneous glomerulonephritis or with systemic lupus erythematosus by light microscopy, electron microscopy, light microscopic immunohistology and by immunoelectron microscopy using the postembedding technique applied to LR-White embedded tissue. Aim of the study was to explore whether immunoelectron microscopy is reproduced on routine biopsy material and in accordance with light microscopic immunohistological findings. The study shows that immunoelectron microscopy can be applied to routine biopsy material and gives reproducible results. The applied method proved to be reliable, and, hence, routine biopsy material may be used for further studies concerning subcellular mechanisms in immunocomplex deposition and removal.

Original languageEnglish
Pages (from-to)417-422
Number of pages6
JournalPathology Research and Practice
Volume190
Issue number5
Publication statusPublished - 1994

Keywords

  • Immunoelectron microscopy
  • Kidney
  • Routine biopsy material

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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