Immunoexpression of SPANX-C in metastatic uveal melanoma

Lucia Salvatorelli, Lidia Puzzo, Andrea Russo, Michele Reibaldi, Antonio Longo, Marco Ragusa, Calogero Aldo, Giancarlo Rappazzo, Rosario Caltabiano, Michele Salemi

Research output: Contribution to journalArticlepeer-review


Uveal melanoma is a rare disease but it is the most common primary intraocular malignant tumor in adults with poor late prognosis. About 50% of patients will develop liver metastasis far from the enucleation within 10–15 years. Our study examined SPANX-C expression levels in primary uveal melanoma both with and without metastasis to assess if they can be used to predict metastasis. This study included a total of 55 patients, 28 males and 27 females, with uveal melanoma. A significantly high expression of SPANX-C was seen in 19/23 (82.6%) patients with metastasis, and only in 11/32 (38.5%) patients without metastasis. In conclusion, we found that SPANX-C expression could play a role in tumor progression of uveal melanoma.

Original languageEnglish
Article number152431
JournalPathology Research and Practice
Publication statusPublished - Jan 1 2019


  • Immunohistochemistry
  • Metastasis
  • Trailblazer cells
  • Uveal melanoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology


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