AUTOANTICORPI IN IMMUNOFLUORESCENZA NELLE EPATOPATIE

Translated title of the contribution: Immunofluorescent autoantibodies in hepatic diseases

S. R. Fargion, E. Del Ninno, M. D. Cappellini, G. Fiorelli

Research output: Contribution to journalArticle

Abstract

Autoantibodies to nuclei (ANA), smooth muscles (SMA), mitochondria (AMA), thyroid (microsomal) and gastric parietal cells were looked for in 137 patients with acute and chronic liver disease. In acute hepatitis (13 cases) the incidence was: ANA in 1 (7%), AMA in 0, SMA in 7 (53%), antithyroid in 1 (7%), and antigastric parietal cells in 3 (23%). In chronic persistent hepatitis (29) the incidence was: ANA in 0, AMA in 1 (3%), SMA in 5 (16%), antithyroid in 2 (7%), and antigastric parietal cells in 3 (10%). In chronic aggressive hepatitis (30) the incidence was: ANA in 3 (10%), AMA in 1 (3%), SMA in 10 (33%), antithyroid in 3 (10%), and antigastric parietal cells in 3 (10%). Moreover the incidence of SMA was different when Au positive patients were considered separately, accounting for 29%, against 45% in Au negative patients. In postnecrotic cirrhosis (24) the incidence of autoantibodies was: ANA in 1 (2%), AMA in 0, SMA in 7 (29%), antithyroid in 3 (12%), and antigastric parietal cells in 2 (10%). In primary biliary cirrhosis (10) [ANA in 1 (10%) and SMA in 2 (20%)] there was a high frequency of AMA [AMA in 9 (90%)]; in 6 patients titers were found to be greater than 1:320. In relatives (20) of 4 patients with primary biliary cirrhosis: ANA in 3 (15%), AMA in 1 (5%), SMA in 0, antithyroid in 4 (20%), antigastric parietal cells in 2 (10%). In cases of long lasting extrahepatic cholestasis (11) AMA was absent, except in one patient with main duct obstruction, due to lymph node enlargement, who had a titer greater than 1:320.

Original languageItalian
Pages (from-to)169-175
Number of pages7
JournalOspedale Maggiore
Volume68
Issue number3
Publication statusPublished - 1973

Fingerprint

Autoantibodies
Mitochondria
Liver
Incidence
Biliary Liver Cirrhosis
Chronic Hepatitis
Extrahepatic Cholestasis
Gastric Parietal Cells
Muscle Mitochondrion
Hepatitis
Smooth Muscle
Liver Diseases
Thyroid Gland
Fibrosis
Chronic Disease
Lymph Nodes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

AUTOANTICORPI IN IMMUNOFLUORESCENZA NELLE EPATOPATIE. / Fargion, S. R.; Del Ninno, E.; Cappellini, M. D.; Fiorelli, G.

In: Ospedale Maggiore, Vol. 68, No. 3, 1973, p. 169-175.

Research output: Contribution to journalArticle

Fargion, SR, Del Ninno, E, Cappellini, MD & Fiorelli, G 1973, 'AUTOANTICORPI IN IMMUNOFLUORESCENZA NELLE EPATOPATIE', Ospedale Maggiore, vol. 68, no. 3, pp. 169-175.
Fargion, S. R. ; Del Ninno, E. ; Cappellini, M. D. ; Fiorelli, G. / AUTOANTICORPI IN IMMUNOFLUORESCENZA NELLE EPATOPATIE. In: Ospedale Maggiore. 1973 ; Vol. 68, No. 3. pp. 169-175.
@article{6a53a0bd39e04949bc427ce9acc0731b,
title = "AUTOANTICORPI IN IMMUNOFLUORESCENZA NELLE EPATOPATIE",
abstract = "Autoantibodies to nuclei (ANA), smooth muscles (SMA), mitochondria (AMA), thyroid (microsomal) and gastric parietal cells were looked for in 137 patients with acute and chronic liver disease. In acute hepatitis (13 cases) the incidence was: ANA in 1 (7{\%}), AMA in 0, SMA in 7 (53{\%}), antithyroid in 1 (7{\%}), and antigastric parietal cells in 3 (23{\%}). In chronic persistent hepatitis (29) the incidence was: ANA in 0, AMA in 1 (3{\%}), SMA in 5 (16{\%}), antithyroid in 2 (7{\%}), and antigastric parietal cells in 3 (10{\%}). In chronic aggressive hepatitis (30) the incidence was: ANA in 3 (10{\%}), AMA in 1 (3{\%}), SMA in 10 (33{\%}), antithyroid in 3 (10{\%}), and antigastric parietal cells in 3 (10{\%}). Moreover the incidence of SMA was different when Au positive patients were considered separately, accounting for 29{\%}, against 45{\%} in Au negative patients. In postnecrotic cirrhosis (24) the incidence of autoantibodies was: ANA in 1 (2{\%}), AMA in 0, SMA in 7 (29{\%}), antithyroid in 3 (12{\%}), and antigastric parietal cells in 2 (10{\%}). In primary biliary cirrhosis (10) [ANA in 1 (10{\%}) and SMA in 2 (20{\%})] there was a high frequency of AMA [AMA in 9 (90{\%})]; in 6 patients titers were found to be greater than 1:320. In relatives (20) of 4 patients with primary biliary cirrhosis: ANA in 3 (15{\%}), AMA in 1 (5{\%}), SMA in 0, antithyroid in 4 (20{\%}), antigastric parietal cells in 2 (10{\%}). In cases of long lasting extrahepatic cholestasis (11) AMA was absent, except in one patient with main duct obstruction, due to lymph node enlargement, who had a titer greater than 1:320.",
author = "Fargion, {S. R.} and {Del Ninno}, E. and Cappellini, {M. D.} and G. Fiorelli",
year = "1973",
language = "Italian",
volume = "68",
pages = "169--175",
journal = "Ospedale Maggiore",
issn = "0369-7843",
publisher = "Masson Italia Periodici",
number = "3",

}

TY - JOUR

T1 - AUTOANTICORPI IN IMMUNOFLUORESCENZA NELLE EPATOPATIE

AU - Fargion, S. R.

AU - Del Ninno, E.

AU - Cappellini, M. D.

AU - Fiorelli, G.

PY - 1973

Y1 - 1973

N2 - Autoantibodies to nuclei (ANA), smooth muscles (SMA), mitochondria (AMA), thyroid (microsomal) and gastric parietal cells were looked for in 137 patients with acute and chronic liver disease. In acute hepatitis (13 cases) the incidence was: ANA in 1 (7%), AMA in 0, SMA in 7 (53%), antithyroid in 1 (7%), and antigastric parietal cells in 3 (23%). In chronic persistent hepatitis (29) the incidence was: ANA in 0, AMA in 1 (3%), SMA in 5 (16%), antithyroid in 2 (7%), and antigastric parietal cells in 3 (10%). In chronic aggressive hepatitis (30) the incidence was: ANA in 3 (10%), AMA in 1 (3%), SMA in 10 (33%), antithyroid in 3 (10%), and antigastric parietal cells in 3 (10%). Moreover the incidence of SMA was different when Au positive patients were considered separately, accounting for 29%, against 45% in Au negative patients. In postnecrotic cirrhosis (24) the incidence of autoantibodies was: ANA in 1 (2%), AMA in 0, SMA in 7 (29%), antithyroid in 3 (12%), and antigastric parietal cells in 2 (10%). In primary biliary cirrhosis (10) [ANA in 1 (10%) and SMA in 2 (20%)] there was a high frequency of AMA [AMA in 9 (90%)]; in 6 patients titers were found to be greater than 1:320. In relatives (20) of 4 patients with primary biliary cirrhosis: ANA in 3 (15%), AMA in 1 (5%), SMA in 0, antithyroid in 4 (20%), antigastric parietal cells in 2 (10%). In cases of long lasting extrahepatic cholestasis (11) AMA was absent, except in one patient with main duct obstruction, due to lymph node enlargement, who had a titer greater than 1:320.

AB - Autoantibodies to nuclei (ANA), smooth muscles (SMA), mitochondria (AMA), thyroid (microsomal) and gastric parietal cells were looked for in 137 patients with acute and chronic liver disease. In acute hepatitis (13 cases) the incidence was: ANA in 1 (7%), AMA in 0, SMA in 7 (53%), antithyroid in 1 (7%), and antigastric parietal cells in 3 (23%). In chronic persistent hepatitis (29) the incidence was: ANA in 0, AMA in 1 (3%), SMA in 5 (16%), antithyroid in 2 (7%), and antigastric parietal cells in 3 (10%). In chronic aggressive hepatitis (30) the incidence was: ANA in 3 (10%), AMA in 1 (3%), SMA in 10 (33%), antithyroid in 3 (10%), and antigastric parietal cells in 3 (10%). Moreover the incidence of SMA was different when Au positive patients were considered separately, accounting for 29%, against 45% in Au negative patients. In postnecrotic cirrhosis (24) the incidence of autoantibodies was: ANA in 1 (2%), AMA in 0, SMA in 7 (29%), antithyroid in 3 (12%), and antigastric parietal cells in 2 (10%). In primary biliary cirrhosis (10) [ANA in 1 (10%) and SMA in 2 (20%)] there was a high frequency of AMA [AMA in 9 (90%)]; in 6 patients titers were found to be greater than 1:320. In relatives (20) of 4 patients with primary biliary cirrhosis: ANA in 3 (15%), AMA in 1 (5%), SMA in 0, antithyroid in 4 (20%), antigastric parietal cells in 2 (10%). In cases of long lasting extrahepatic cholestasis (11) AMA was absent, except in one patient with main duct obstruction, due to lymph node enlargement, who had a titer greater than 1:320.

UR - http://www.scopus.com/inward/record.url?scp=0015717946&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015717946&partnerID=8YFLogxK

M3 - Articolo

AN - SCOPUS:0015717946

VL - 68

SP - 169

EP - 175

JO - Ospedale Maggiore

JF - Ospedale Maggiore

SN - 0369-7843

IS - 3

ER -