Immunogenetic and hormonal study of cryptorchidism

M. Martinetti, M. Maghnie, L. Salvaneschi, N. Di Ninno, C. Daielli, G. Palladini, M. Cuccia

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Ninety-four cryptorchids, 50 monolateral and 44 bilateral, aged from 2-9.4 yr (mean, 5.1 ± 0.5 yr), were studied for the hormonal and immunogenetic profile. Pituitary-gonadal function was studied by evaluation of basal and peak GnRH-stimulated serum FSH and LH. In 83 cases, the serum testosterone (T) level was measured before and after CG treatment. No significant differences, between patients and age-matched controls, were found in either FSH or LH levels, whether under basal conditions or after GHRH stimulation. The mean basal serum T level was similar in mono and bilateral cryptorchids and in controls but, on the 15th day after treatment, it was significantly lower in the bilateral cryptorchids (P <0.05). CG administration led to testicular descent in 42 patients (23 with monolateral and 19 with bilateral cryptorchidism) and failed in 41 (21 with monolateral and 20 with bilateral cryptorchidism), independently of T increase. Immunogenetic investigation demonstrated that HLA-A11 and A23 were significantly overrepresented in the whole group of cryptorchids in comparison with the controls (P = 0.004 and P = 0.0123, respectively). HLA-A11 was more common in the bilateral form (P <0.05), whereas HLA-A29 was more frequent in the monolateral one (P <0.05). Forty percent of the bilateral cryptorchids with unsuccessful treatment had the HLA-A11 allele (P <0.01) and 70% the HLA-DR5.

Original languageEnglish
Pages (from-to)39-42
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Issue number1
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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