Immunogenetics features and genomic lesions in splenic marginal zone lymphoma

Andrea Rinaldi, Francesco Forconi, Luca Arcaini, Michael Mian, Elena Sozzi, Silvia Zibellini, Luca Baldini, Silvia Franceschetti, Gianluca Gaidano, Roberto Marasca, Manuela Mollejo, Miguel A. Piris, Alessandra Tucci, Fabio Facchetti, Govind Bhagat, Riccardo D. Favera, Paola M V Rancoita, Emanuele Zucca, Ivo Kwee, Francesco Bertoni

Research output: Contribution to journalArticlepeer-review

Abstract

Splenic marginal zone lymphomas (MZL) express mutated (M-) or unmutated (U-) immunoglobulin heavy chain (IGHV) genes. To investigate the IGHV mutational status impact on genetic lesions, this study combined single nucleotide polymorphism-arrays and IGHV sequencing in 83 cases. Clinical features and outcome were similar between U- and M-IGHV cases. Recurrent lesions frequency was higher in U-IGHV cases, including poor prognosticators. Frequencies differed among cases bearing individual IGHV genes or lambda light chains. In conclusion, SMZL comprises subgroups based on genetic abnormalities and immunogenetic status. Genomic lesion frequency differed and was higher in U-IGHV cases, possibly affecting the outcome.

Original languageEnglish
Pages (from-to)435-439
Number of pages5
JournalBritish Journal of Haematology
Volume151
Issue number5
DOIs
Publication statusPublished - Dec 2010

Keywords

  • CGH
  • Immunogenetics
  • Immunoglobulin genes
  • Lymphomas
  • Microarray
  • Spleen

ASJC Scopus subject areas

  • Hematology

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