In a previous work we demonstrated a strong association between HLA-B7 and the susceptibility to the Lennox Gastaut syndrome. In this work we report some preliminary results obtained performing one-way mixed lymphocyte cultures in vitro between 15 unrelated children showing the typical EEG and clinical patterns of the syndrome. The same children were also tested against unrelated control cells from healthy donors. The low stimulation displayed by Lennox-Gastaut patients between them as compared with the higher stimulation found in patients/controls and controls/controls comparisons suggests the existence of an LD allele which may be associated with the disease.
|Number of pages||8|
|Journal||Bollettino dell'Istituto Sieroterapico Milanese|
|Publication status||Published - 1977|
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