Immunogenetics of Lennox-Gastaut syndrome

search for LD determinants as genetic markers of the syndrome

E. Smeraldi, R. Scorza-Smeraldi, A. Guareschi-Cazzullo, C. Rugarli, R. Canger, M. G. Sabbadini

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In a previous work we demonstrated a strong association between HLA-B7 and the susceptibility to the Lennox Gastaut syndrome. In this work we report some preliminary results obtained performing one-way mixed lymphocyte cultures in vitro between 15 unrelated children showing the typical EEG and clinical patterns of the syndrome. The same children were also tested against unrelated control cells from healthy donors. The low stimulation displayed by Lennox-Gastaut patients between them as compared with the higher stimulation found in patients/controls and controls/controls comparisons suggests the existence of an LD allele which may be associated with the disease.

Original languageEnglish
Pages (from-to)544-551
Number of pages8
JournalBollettino dell'Istituto Sieroterapico Milanese
Volume56
Issue number6
Publication statusPublished - 1977

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Immunogenetics
Genetic Markers
HLA-B7 Antigen
Electroencephalography
Alleles
Tissue Donors
Lymphocytes
Lennox Gastaut Syndrome
In Vitro Techniques

ASJC Scopus subject areas

  • Immunology

Cite this

Smeraldi, E., Scorza-Smeraldi, R., Guareschi-Cazzullo, A., Rugarli, C., Canger, R., & Sabbadini, M. G. (1977). Immunogenetics of Lennox-Gastaut syndrome: search for LD determinants as genetic markers of the syndrome. Bollettino dell'Istituto Sieroterapico Milanese, 56(6), 544-551.

Immunogenetics of Lennox-Gastaut syndrome : search for LD determinants as genetic markers of the syndrome. / Smeraldi, E.; Scorza-Smeraldi, R.; Guareschi-Cazzullo, A.; Rugarli, C.; Canger, R.; Sabbadini, M. G.

In: Bollettino dell'Istituto Sieroterapico Milanese, Vol. 56, No. 6, 1977, p. 544-551.

Research output: Contribution to journalArticle

Smeraldi, E, Scorza-Smeraldi, R, Guareschi-Cazzullo, A, Rugarli, C, Canger, R & Sabbadini, MG 1977, 'Immunogenetics of Lennox-Gastaut syndrome: search for LD determinants as genetic markers of the syndrome', Bollettino dell'Istituto Sieroterapico Milanese, vol. 56, no. 6, pp. 544-551.
Smeraldi E, Scorza-Smeraldi R, Guareschi-Cazzullo A, Rugarli C, Canger R, Sabbadini MG. Immunogenetics of Lennox-Gastaut syndrome: search for LD determinants as genetic markers of the syndrome. Bollettino dell'Istituto Sieroterapico Milanese. 1977;56(6):544-551.
Smeraldi, E. ; Scorza-Smeraldi, R. ; Guareschi-Cazzullo, A. ; Rugarli, C. ; Canger, R. ; Sabbadini, M. G. / Immunogenetics of Lennox-Gastaut syndrome : search for LD determinants as genetic markers of the syndrome. In: Bollettino dell'Istituto Sieroterapico Milanese. 1977 ; Vol. 56, No. 6. pp. 544-551.
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