Immunogenicity and safety of intradermal influenza vaccine in children

Susanna Esposito, Cristina Daleno, Irene Picciolli, Laura Tagliaferri, Alessia Scala, Giulia Prunotto, Valentina Montinaro, Carlotta Galeone, Nicola Principi

Research output: Contribution to journalArticlepeer-review

Abstract

In order to compare the immunogenicity and safety of different doses of trivalent influenza vaccine (TIV) administered intradermallly (ID) with those evoked by a full dose of intramuscular (IM) virosomal-adjuvanted influenza vaccine (VA-TIV), 112 previously primed healthy children aged ≥3 years were randomised to receive 9 μg or 15 μg of each strain of ID-TIV, or a full IM dose (15 μg of each strain) of VA-TIV. The A/H1N1 and A/H3N2 seroconversion and seroprotection rates were ≥90% and geometric mean titres (GMTs) increased 3.2-14.9 times without any statistically significant between-group differences; however, the seroconversion and seroprotection rates against the B strain were significantly higher in the children receiving either ID-TIV dose (p<0.05) without any differences between them. GMT against B virus was significantly higher in the children receiving the highest dose (p<0.05). Local reactions were significantly more common among the children receiving either ID-TIV dose (p<0.05), but systemic reactions were relatively uncommon in all three groups. Our findings suggest that ID-TIV with 15 μg of each viral antigen can confer a significant better protection against influenza than that obtained with the same dose of IM TIV in already primed children aged ≥3 years with an acceptable safety profile. The lower dose of ID-TIV needs further evaluation to analyze persistence of protection.

Original languageEnglish
Pages (from-to)7606-7610
Number of pages5
JournalVaccine
Volume29
Issue number44
DOIs
Publication statusPublished - Oct 13 2011

Keywords

  • Children
  • Influenza
  • Influenza vaccination
  • Intradermal influenza vaccine
  • Pediatrics

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)
  • Molecular Medicine

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