Immunogenicity and safety of the human papillomavirus vaccine in patients with autoimmune diseases: A systematic review

Paolo Pellegrino, Sonia Radice, Emilio Clementi

Research output: Contribution to journalArticlepeer-review

Abstract

Whereas safety and efficacy of HPV vaccines in healthy women have been shown in several randomised controlled clinical trials and in post marketing analyses, only few data exist in patients affected by autoimmune diseases. These issues are significant as autoimmune conditions are recognised as a risk factor for the persistence of HPV infection. Herein we review and systematise the existing literature to assess immunogenicity and safety of HPV vaccination in patients with autoimmune diseases, including systemic lupus erythematosus and juvenile idiopathic arthritis.The results of our literature revision suggest that the HPV vaccines are efficacious and safe in most of the patients affected by autoimmune diseases. Yet, some points of concern remain to be tackled, including the effects of concomitant therapies, the risk of disease exacerbation and the cost-effectiveness of such immunisation programmes in these populations.

Original languageEnglish
Pages (from-to)3444-3449
Number of pages6
JournalVaccine
Volume33
Issue number30
DOIs
Publication statusPublished - Jul 9 2015

Keywords

  • Autoimmune diseases
  • Cost-effectiveness
  • HPV vaccines
  • Safety

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)
  • Molecular Medicine

Fingerprint Dive into the research topics of 'Immunogenicity and safety of the human papillomavirus vaccine in patients with autoimmune diseases: A systematic review'. Together they form a unique fingerprint.

Cite this