Immunogenicity of hepatitis A-inactivated vaccine administered to seronegative infants, and serological follow-up 12 months after second dose

Annalisa De Silvestri, Francesca Zara, Virginio Terulla, Roberto Brerra, Silvana Zucca, Cesare Belloni

Research output: Contribution to journalArticle

Abstract

Aim: To evaluate a) the safety and immunogenicity of anti-HAV-inactivated vaccine administered during the first year of life to anti-HAV seronegative babies, and b) the antibody persistence in a low/intermediate endemic area. Methods: After having obtained informed written consent from mothers, 92 babies were vaccinated at 4 and 10 mo of age. All babies were seronegative at birth and did not present HAV-RNA shedding in three serial stool samples taken at 1, 2 and 3 mo of age. Results: No general side effects (fever > 38°C) were observed. After the first dose of vaccine, 70/82 (85.4%) babies developed anti-HAV > 10 mIU/ml and 36/82 (43.9%) > 20 mIU/ml. After the second dose of vaccine, all babies developed a titre > 20 mIU/ml, and GMT was 877 mIU/ml. After 1 y of follow-up, the decreasing rate was similar to that reported for adult populations. Furthermore, three babies doubled the titre observed 1 mo after the second dose, indicating the possible spread of HAV even in a low/intermediate endemic area. Conclusion: Anti-HAV vaccine is safe, immunogenic and able to induce immune memory, and can be integrated into the routine infant immunization schedule during the first year of life.

Original languageEnglish
Pages (from-to)1582-1585
Number of pages4
JournalActa Paediatrica, International Journal of Paediatrics
Volume95
Issue number12
DOIs
Publication statusPublished - Dec 1 2006

Keywords

  • Anti-HAV vaccine
  • Immunization
  • Infants

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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