Immunogenicity of hepatitis B vaccine in term and preterm infants

C. Belloni, G. Chirico, A. Pistorio, P. Orsolini, C. Tinelli, G. Rondini

Research output: Contribution to journalArticlepeer-review


Some studies have suggested that decreased seroconversion rates might be found in premature infants with low birthweight (<2000 g) following administration of hepatitis B vaccine at birth. The aim of the present investigation was to evaluate possible differences in seropositive rates between full-term and preterm infants after primary vaccination, in particular when gestational age or birthweight is very low. Two-thousand and nine neonates born to HBsAg-negative mothers were vaccinated with 10 μg of recombinant hepatitis B virus (HBV) vaccine, from May 1991 to October 1994. Children with infections, congenital malformations or serious illnesses were excluded. HBV vaccine was administered intramuscularly, on the fourth day of life and again at 1 and 6 months of age. A 1-ml blood sample was drawn from each infant 1 month after the third vaccine dose for determination of the level of anti-HBs antibody. The response to HBV vaccination was evaluated in 241 preterm (gestational age

Original languageEnglish
Pages (from-to)336-338
Number of pages3
JournalActa Paediatrica, International Journal of Paediatrics
Issue number3
Publication statusPublished - 1998


  • Hepatitis B vaccination
  • Immune response
  • Newborn
  • Preterm infant

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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