Immunogenicity of HIV virus-like particles in rhesus macaques by intranasal administration

Luigi Buonaguro, Maria Tagliamonte, Maria Luisa Visciano, Hanne Andersen, Mark Lewis, Ranajit Pal, Maria Lina Tornesello, Ulf Schroeder, Jorma Hinkula, Britta Wahren, Franco M. Buonaguro

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Abstract

Female rhesus macaques were immunized with HIV virus-like particles (HIV-VLPs) or HIV DNA administered as sequential combinations of mucosal (intranasal) and systemic (intramuscular) routes, according to homologous or heterologous primeboost schedules. The results show that in rhesus macaques only the sequential intranasal and intramuscular administration of HIV-VLPs, and not the intranasal alone, is able to elicit humoral immune response at the systemic as well as the vaginal level.

Original languageEnglish
Pages (from-to)970-973
Number of pages4
JournalClinical and Vaccine Immunology
Volume19
Issue number6
DOIs
Publication statusPublished - Jun 2012

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ASJC Scopus subject areas

  • Clinical Biochemistry
  • Immunology
  • Immunology and Allergy
  • Microbiology (medical)

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