Immunogenicity of meningococcal quadrivalent (serogroup A, C, W135 and Y) tetanus toxoid conjugate vaccine: Systematic review and meta-analysis

Paolo Pellegrino, Valentina Perrone, Sonia Radice, Annalisa Capuano, Emilio Clementi

Research output: Contribution to journalArticlepeer-review

Abstract

Meningococcal meningitis represents one of the leading cause of bacterial meningitis in developed countries. Among the thirteen described serogroups, only five are usually responsible of invasive infections making immunisation against multiple serogroups the best strategy to protect individuals from this disease. Herein we carried out a systematic review and meta-analysis, in accordance with the PRISMA statement, of the recently EU-licensed meningococcal ACWY-tetanus toxoid conjugate vaccine (MenACWY-TT). We included 15 randomised clinical trials, comparing MenACWY-TT and Men-PS (ten studies), MenACWY-TT and MenC-CRM197 (four studies) and MenACWY-TT and MenACWY-DT (one study). All studies included in the meta-analysis showed high immunogenicity for MenACWY-TT vaccines in all tested serogroups. Our results suggest that the MenACWY-TT vaccine is as immunogenic as the other commercial avaiable meningococcal vaccines.

Original languageEnglish
Pages (from-to)31-39
Number of pages9
JournalPharmacological Research
Volume92
DOIs
Publication statusPublished - 2015

Keywords

  • MenACWY-TT
  • Meningococcal meningitis
  • Meningococcal vaccine

ASJC Scopus subject areas

  • Pharmacology
  • Medicine(all)

Fingerprint Dive into the research topics of 'Immunogenicity of meningococcal quadrivalent (serogroup A, C, W135 and Y) tetanus toxoid conjugate vaccine: Systematic review and meta-analysis'. Together they form a unique fingerprint.

Cite this