Immunogenicity, safety and tolerability of a bivalent human papillomavirus vaccine in adolescents with juvenile idiopathic arthritis

Susanna Esposito, Fabrizia Corona, Luisa Barzon, Federica Cuoco, Laura Squarzon, Giorgia Marcati, Marta Torcoletti, Monia Gambino, Giorgio Palù, Nicola Principi

Research output: Contribution to journalArticle

Abstract

Aims: To evaluate the immunogenicity, safety and tolerability of the bivalent HPV vaccine in female patients with juvenile idiopathic arthritis (JIA). Methods: Twenty-one patients with JIA aged 12-25 years and 21 healthy controls were enrolled and received three doses of the bivalent HPV vaccine. Results: All of the subjects were seronegative at baseline and seroconverted after the scheduled doses. The JIA patients showed significantly lower HPV16 neutralising antibody titres than controls 1 month after the administration of the third dose (p <0.05), whereas no significant difference was observed in HPV18 neutralising antibody titres. Local and systemic reactions were similarly frequent in the patients and controls, and there were no significant changes in 27-joint juvenile arthritis disease activity score or laboratory tests. Conclusion: The bivalent HPV vaccine is safe in patients with stable JIA and regardless of the use of medications the vaccine assures an adequate degree of protection for a certain time.

Original languageEnglish
Pages (from-to)1387-1393
Number of pages7
JournalExpert Review of Vaccines
Volume13
Issue number11
DOIs
Publication statusPublished - Nov 1 2014

Keywords

  • autoimmune disease
  • bivalent papillomavirus vaccine
  • HPV
  • juvenile idiopathic arthritis
  • papillomavirus vaccine
  • rheumatological disease

ASJC Scopus subject areas

  • Immunology
  • Drug Discovery
  • Pharmacology
  • Molecular Medicine
  • Medicine(all)

Fingerprint Dive into the research topics of 'Immunogenicity, safety and tolerability of a bivalent human papillomavirus vaccine in adolescents with juvenile idiopathic arthritis'. Together they form a unique fingerprint.

  • Cite this

    Esposito, S., Corona, F., Barzon, L., Cuoco, F., Squarzon, L., Marcati, G., Torcoletti, M., Gambino, M., Palù, G., & Principi, N. (2014). Immunogenicity, safety and tolerability of a bivalent human papillomavirus vaccine in adolescents with juvenile idiopathic arthritis. Expert Review of Vaccines, 13(11), 1387-1393. https://doi.org/10.1586/14760584.2014.943195