TY - JOUR
T1 - Immunogenomics approaches for vaccine evaluation
AU - Petrizzo, Annacarmen
AU - Tornesello, Marialina
AU - Buonaguro, Franco M.
AU - Buonaguro, Luigi
PY - 2012/7
Y1 - 2012/7
N2 - Vaccines represent a potent tool to prevent or contain diseases with high morbidity or mortality. However, despite their widespread use, there is still a limited understanding of the mechanisms underlying the effective elicitation of protective immune responses by vaccines. The integrated co-operation between cells and molecules of innate and adaptive immune systems is under intense study by several groups and constantly updated. The recent development of new technologies and computational tools permits the comprehensive and quantitative analysis of the interactions between all of the components of immunity over time. This study reviews recent progress in exploiting an immunogenomics approach, within the systems biology strategy, to study and evaluate vaccine strategies for infectious and neoplastic diseases. The final goal of this approach is 2-fold, looking for novel and unpredictable mechanisms as well as identifying common immune signatures, relevant for predicting immune responsiveness to improve the design of vaccine strategies. Such approach, indeed, would enable the switch from 'empirical' to 'knowledge-based' vaccinology, leading to a patient-tailored treatment.
AB - Vaccines represent a potent tool to prevent or contain diseases with high morbidity or mortality. However, despite their widespread use, there is still a limited understanding of the mechanisms underlying the effective elicitation of protective immune responses by vaccines. The integrated co-operation between cells and molecules of innate and adaptive immune systems is under intense study by several groups and constantly updated. The recent development of new technologies and computational tools permits the comprehensive and quantitative analysis of the interactions between all of the components of immunity over time. This study reviews recent progress in exploiting an immunogenomics approach, within the systems biology strategy, to study and evaluate vaccine strategies for infectious and neoplastic diseases. The final goal of this approach is 2-fold, looking for novel and unpredictable mechanisms as well as identifying common immune signatures, relevant for predicting immune responsiveness to improve the design of vaccine strategies. Such approach, indeed, would enable the switch from 'empirical' to 'knowledge-based' vaccinology, leading to a patient-tailored treatment.
KW - Adaptive immunity
KW - Immunogenomics
KW - Innate immunity
KW - Systems biology
KW - Vaccine
UR - http://www.scopus.com/inward/record.url?scp=84865323051&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865323051&partnerID=8YFLogxK
U2 - 10.3109/1547691X.2012.707698
DO - 10.3109/1547691X.2012.707698
M3 - Article
C2 - 22894136
AN - SCOPUS:84865323051
VL - 9
SP - 236
EP - 240
JO - Journal of Immunotoxicology
JF - Journal of Immunotoxicology
SN - 1547-691X
IS - 3
ER -