Immunoglobulin and T-cell receptor gene rearrangements in Hodgkin's disease and Ki-1-positive anaplastic large cell lymphoma: Dissociation between phenotype and genotype

Hermann Herbst; Gerald Tippelmann; Ioannis Anagnostopoulos; Johannes Gerdes; Roland Schwarting; Thomas Boehm; Stefano Pileri; David B. Jones; Harald Stein

doi:10.1016/0145-2126(89)90134-3

Immunoglobulin and T-cell receptor gene rearrangements in Hodgkin's disease and Ki-1-positive anaplastic large cell lymphoma: Dissociation between phenotype and genotype

Hermann Herbst, Gerald Tippelmann, Ioannis Anagnostopoulos, Johannes Gerdes, Roland Schwarting, Thomas Boehm, Stefano Pileri, David B. Jones, Harald Stein

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

We have determined the tumor cell immunophenotype and the rearrangement configuration of immunoglobulin and T-cell receptor genes in 39 cases of Hodgkin's disease (HD), six HD-derived cell lines and 22 cases of Ki-1-positive anaplastic large cell lymphomas (Ki-1-ALC). Rearrangements were observed in 11 39 HD cases, 15 22 Ki-1-ALC, and all cell lines. Epstein-Barr virus DNA was found in five HD cases, one cell line, and one Ki-1-ALC. Both HD and Ki-1-ALC frequently displayed a dissociated genotypic and phenotypic maturation status, i.e. an immature genotype in association with late activation markers. We postulate that the tumor cells in many cases of HD and some cases of Ki-1-ALC may be derived from immature lymphoid cells by a transformation process that superimposes characteristics of mature activated lymphocytes on these cells.

Original language	English
Journal	Leukemia Research
Volume	13
Issue number	2
DOIs	https://doi.org/10.1016/0145-2126(89)90134-3
Publication status	Published - 1989

Keywords

Epstein-Barr virus
gene rearrangement
Hodgkin's disease
immunoglobulin genes
Ki-1 lymphoma
phenotype
T-cell receptor genes

ASJC Scopus subject areas

Cancer Research
Hematology
Oncology

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10.1016/0145-2126(89)90134-3

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Herbst, H., Tippelmann, G., Anagnostopoulos, I., Gerdes, J., Schwarting, R., Boehm, T., Pileri, S., Jones, D. B., & Stein, H. (1989). Immunoglobulin and T-cell receptor gene rearrangements in Hodgkin's disease and Ki-1-positive anaplastic large cell lymphoma: Dissociation between phenotype and genotype. Leukemia Research, 13(2). https://doi.org/10.1016/0145-2126(89)90134-3

Herbst, H, Tippelmann, G, Anagnostopoulos, I, Gerdes, J, Schwarting, R, Boehm, T, Pileri, S, Jones, DB & Stein, H 1989, 'Immunoglobulin and T-cell receptor gene rearrangements in Hodgkin's disease and Ki-1-positive anaplastic large cell lymphoma: Dissociation between phenotype and genotype', Leukemia Research, vol. 13, no. 2. https://doi.org/10.1016/0145-2126(89)90134-3

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abstract = "We have determined the tumor cell immunophenotype and the rearrangement configuration of immunoglobulin and T-cell receptor genes in 39 cases of Hodgkin's disease (HD), six HD-derived cell lines and 22 cases of Ki-1-positive anaplastic large cell lymphomas (Ki-1-ALC). Rearrangements were observed in 11 39 HD cases, 15 22 Ki-1-ALC, and all cell lines. Epstein-Barr virus DNA was found in five HD cases, one cell line, and one Ki-1-ALC. Both HD and Ki-1-ALC frequently displayed a dissociated genotypic and phenotypic maturation status, i.e. an immature genotype in association with late activation markers. We postulate that the tumor cells in many cases of HD and some cases of Ki-1-ALC may be derived from immature lymphoid cells by a transformation process that superimposes characteristics of mature activated lymphocytes on these cells.",

keywords = "Epstein-Barr virus, gene rearrangement, Hodgkin's disease, immunoglobulin genes, Ki-1 lymphoma, phenotype, T-cell receptor genes",

author = "Hermann Herbst and Gerald Tippelmann and Ioannis Anagnostopoulos and Johannes Gerdes and Roland Schwarting and Thomas Boehm and Stefano Pileri and Jones, {David B.} and Harald Stein",

year = "1989",

doi = "10.1016/0145-2126(89)90134-3",

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AU - Herbst, Hermann

AU - Tippelmann, Gerald

AU - Anagnostopoulos, Ioannis

AU - Gerdes, Johannes

AU - Schwarting, Roland

AU - Boehm, Thomas

AU - Pileri, Stefano

AU - Jones, David B.

AU - Stein, Harald

PY - 1989

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N2 - We have determined the tumor cell immunophenotype and the rearrangement configuration of immunoglobulin and T-cell receptor genes in 39 cases of Hodgkin's disease (HD), six HD-derived cell lines and 22 cases of Ki-1-positive anaplastic large cell lymphomas (Ki-1-ALC). Rearrangements were observed in 11 39 HD cases, 15 22 Ki-1-ALC, and all cell lines. Epstein-Barr virus DNA was found in five HD cases, one cell line, and one Ki-1-ALC. Both HD and Ki-1-ALC frequently displayed a dissociated genotypic and phenotypic maturation status, i.e. an immature genotype in association with late activation markers. We postulate that the tumor cells in many cases of HD and some cases of Ki-1-ALC may be derived from immature lymphoid cells by a transformation process that superimposes characteristics of mature activated lymphocytes on these cells.

AB - We have determined the tumor cell immunophenotype and the rearrangement configuration of immunoglobulin and T-cell receptor genes in 39 cases of Hodgkin's disease (HD), six HD-derived cell lines and 22 cases of Ki-1-positive anaplastic large cell lymphomas (Ki-1-ALC). Rearrangements were observed in 11 39 HD cases, 15 22 Ki-1-ALC, and all cell lines. Epstein-Barr virus DNA was found in five HD cases, one cell line, and one Ki-1-ALC. Both HD and Ki-1-ALC frequently displayed a dissociated genotypic and phenotypic maturation status, i.e. an immature genotype in association with late activation markers. We postulate that the tumor cells in many cases of HD and some cases of Ki-1-ALC may be derived from immature lymphoid cells by a transformation process that superimposes characteristics of mature activated lymphocytes on these cells.

KW - Epstein-Barr virus

KW - gene rearrangement

KW - Hodgkin's disease

KW - immunoglobulin genes

KW - Ki-1 lymphoma

KW - phenotype

KW - T-cell receptor genes

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JO - Leukemia Research

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Immunoglobulin and T-cell receptor gene rearrangements in Hodgkin's disease and Ki-1-positive anaplastic large cell lymphoma: Dissociation between phenotype and genotype

Abstract

Keywords

ASJC Scopus subject areas

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