Immunoglobulin E and bullous pemphigoid

Emanuele Cozzani, Giulia Gasparini, Giovanni Di Zenzo, Aurora Parodi

Research output: Contribution to journalArticlepeer-review

Abstract

Clinical features and histological findings in bullous pemphigoid (BP) suggest a Th2-oriented inflammatory reaction, especially in the early stages of the disease. Elevated total serum IgE levels, blood eosinophilia, and elevated serum levels of different soluble inflammatory Th2 response mediators have been described in large cohorts of patients with classic clear-cut BP manifestations. Direct immunofluorescence, indirect immunofluorescence, and anti-BP230 and anti-BP180 IgE ELISA testing show self-reactive IgE autoantibodies in a consistent number of BP patients. Both IgE autoantibodies and a Th2-oriented immune response may play a role in the initial phases of BP and atypical cases of BP, such as severe erythematous and urticarial forms of BP, as well as blister formation. Two recently reported experimental murine models employing IgE autoantibodies against BP180 have been reported and the successful treatment of bullous pemphigoid with the anti-IgE antibody, omalizumab, supports the roles played by IgE autoantibodies in BP pathogenesis.

Original languageEnglish
Pages (from-to)440-448
Number of pages9
JournalEuropean journal of dermatology : EJD
Volume28
Issue number4
DOIs
Publication statusPublished - Aug 1 2018

Keywords

  • anti-BP230 and anti-BP180 IgE
  • bullous pemphigoid
  • omalizumab
  • Th2

ASJC Scopus subject areas

  • Dermatology

Fingerprint Dive into the research topics of 'Immunoglobulin E and bullous pemphigoid'. Together they form a unique fingerprint.

Cite this