Immunoglobulin G subclass deficiencies

T. Söderström, R. Söderström, A. Avanzini, P. Brandtzaeg, G. Karlsson, L. Hanson

Research output: Contribution to journalArticlepeer-review

Abstract

Low levels of single or multiple serum immunoglobulin G (IgG) subclasses is a common finding among patients with increased susceptibility to infections. In this investigation we summarize data from studies of 503 subclass-deficient individuals. Low IgG2 levels was the most common deficiency among children, and boys were more often deficient than girls. From the age of 16, females dominated, and the most frequent finding was low IgG3 levels. In vitro T or B lymphocyte dysfunction was demonstrated in 75% of the individuals, suggesting that low subclass levels may be indicators of an underlying defect at the B cell or possibly T cell level. Vaccinations and mucosal biopsies were performed to evaluate whichpatients may be helped by immunoglobulin substitution therapy.

Original languageEnglish
Pages (from-to)476-480
Number of pages5
JournalInternational Archives of Allergy and Immunology
Volume82
Issue number3-4
DOIs
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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