Immunoglobulin heavy chain genes somatic hypermutations and chromosome 11q22-23 deletion in classic mantle cell lymphoma: A study of the Swiss Group for Clinical Cancer Research

Francesco Bertoni, Annarita Conconi, Sergio B. Cogliatti, Shu Fang Hsu Schmilz, Michele Ghielmini, Thomas Cerny, Martin Fey, Gabriella Pichert, Francesco Bertolini, Maurilio Ponzoni, Luca Baldini, Chris Jones, Rebecca Auer, Emanuele Zucca, Franco Cavalli, Finbarr E. Cotter

Research output: Contribution to journalArticlepeer-review

Abstract

Mantle cell lymphoma (MCL) shares immunophenotypic and karyotypic features with chronic lymphocytic leukaemia. The latter comprises two distinct entities with prognosis dependent upon immunoglobulin heavy chain (IgH) gene mutational status and the presence of 11q deletion. We evaluated the relevance of IgH gene mutational status, IgV gene family usage and presence of 11q deletion in a series of 42 histologically reviewed classical MCL cases to determine the prognostic impact. VH3 was the most common VH family, with VH3-21 being the most frequent individual VH gene. Approximately 30% of the cases had a IgH somatic mutation rate higher than 2%, but was only higher than 4% in ter), with two minimal deleted regions, at 11q22.2 and 11q23.2. There was no association between 11q loss and IgH gene somatic mutation rate; the use of VH3-21 gene could be associated with a better prognosis.

Original languageEnglish
Pages (from-to)289-298
Number of pages10
JournalBritish Journal of Haematology
Volume124
Issue number3
DOIs
Publication statusPublished - Feb 2004

Keywords

  • Ataxia telangiectasia mutated gene
  • Chromosome 11q
  • Immunoglobulin genes
  • Somatic hypermutation
  • VH genes

ASJC Scopus subject areas

  • Hematology

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