Immunoglobulin-like cell adhesion molecules: Novel signaling players in epithelial ovarian cancer

Lorenzo Bombardelli, Ugo Cavallaro

Research output: Contribution to journalArticlepeer-review

Abstract

Epithelial ovarian cancer is the most lethal gynecological pathology. Recent data implicated certain immunoglobulin-like cell adhesion molecules in ovarian cancer progression. In particular, evidence acquired in ovarian cancer and in other biological contexts, such as the nervous system, support the view that the interplay between immunoglobulin-like cell adhesion molecules and receptor tyrosine kinases contributes to ovarian tumorigenesis. Furthermore, proteolytic processing of immunoglobulin-like cell adhesion molecules gives rise to fragments endowed with biological activities that can support ovarian cancer development. This article will discuss the signaling function of immunoglobulin-like cell adhesion molecules in the context of ovarian cancer progression, an issue that, on one hand, will shed light on novel pathogenic mechanisms and, on the other hand, may offer viable therapeutic targets for such a devastating disease.

Original languageEnglish
Pages (from-to)590-594
Number of pages5
JournalInternational Journal of Biochemistry and Cell Biology
Volume42
Issue number5
DOIs
Publication statusPublished - May 2010

Keywords

  • Epithelial ovarian cancer
  • Ig-CAMs
  • L1
  • Receptor tyrosine kinases
  • Shedding

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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