Immunoglobulin sequence analysis and prognostication in CLL: Guidelines from the ERIC review board for reliable interpretation of problematic cases

A. W. Langerak, F. Davi, P. Ghia, A. Hadzidimitriou, F. Murray, K. N. Potter, R. Rosenquist, K. Stamatopoulos, C. Belessi

Research output: Contribution to journalArticlepeer-review

Abstract

Immunoglobulin gene sequence analysis is widely utilized for prognostication in chronic lymphocytic leukemia (CLL) and the definition of standardized procedures has allowed reliable and reproducible results. Occasionally, a straightforward interpretation of the sequences is not possible because of the so-called problematic sequences that do not fit the classic interpretation and pose scientific questions at the cross-road between hematology and immunology. Thanks to a dedicated effort within the European Research Initiative on CLL (ERIC), we have now the possibility to present such cases, offer a scientific explanation and propose recommendations in terms of prognostication.

Original languageEnglish
Pages (from-to)979-984
Number of pages6
JournalLeukemia
Volume25
Issue number6
DOIs
Publication statusPublished - Jun 2011

Keywords

  • CLL
  • IGHV
  • immunoglobulin
  • prognosis
  • somatic mutation analysis

ASJC Scopus subject areas

  • Hematology
  • Cancer Research
  • Anesthesiology and Pain Medicine

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