TY - JOUR
T1 - Immunohistochemical analysis of an additional case of focal myositis
AU - Macchioni, P.
AU - Boiardi, L.
AU - Meliconi, R.
AU - Salvarani, C.
AU - Pulsatelli, L.
AU - Mancini, R.
AU - Prandi, S.
AU - Facchini, A.
AU - Portioli, I.
PY - 1995
Y1 - 1995
N2 - We present an additional case of focal myositis which, after surgical excision of the muscular mass, did not evolve to generalized polymyositis. To our knowledge immunological evaluations of this disease have never before been carried out. Immunohistochemical analysis of the muscular mass showed the presence of activated endothelial cells, CD4 and macrophage cells in the perivascular and endomysial areas, suggesting an immune-mediated mechanism of muscular damage. At the same time the normal distribution of the peripheral blood lymphocyte subpopulations and the normal levels of serum IL-1β, IL-6, TNF-α, soluble IL-2R and soluble CD8 underline the non-systemic nature of the disease.
AB - We present an additional case of focal myositis which, after surgical excision of the muscular mass, did not evolve to generalized polymyositis. To our knowledge immunological evaluations of this disease have never before been carried out. Immunohistochemical analysis of the muscular mass showed the presence of activated endothelial cells, CD4 and macrophage cells in the perivascular and endomysial areas, suggesting an immune-mediated mechanism of muscular damage. At the same time the normal distribution of the peripheral blood lymphocyte subpopulations and the normal levels of serum IL-1β, IL-6, TNF-α, soluble IL-2R and soluble CD8 underline the non-systemic nature of the disease.
KW - focal myositis
KW - immunohistochemical analysis
UR - http://www.scopus.com/inward/record.url?scp=0029561217&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029561217&partnerID=8YFLogxK
M3 - Article
C2 - 8835251
AN - SCOPUS:0029561217
VL - 13
SP - 753
EP - 757
JO - Clinical and Experimental Rheumatology
JF - Clinical and Experimental Rheumatology
SN - 0392-856X
IS - 6
ER -