Immunohistochemical analysis of an additional case of focal myositis

P. Macchioni; L. Boiardi; R. Meliconi; C. Salvarani; L. Pulsatelli; R. Mancini; S. Prandi; A. Facchini; I. Portioli

Immunohistochemical analysis of an additional case of focal myositis

P. Macchioni, L. Boiardi, R. Meliconi, C. Salvarani, L. Pulsatelli, R. Mancini, S. Prandi, A. Facchini, I. Portioli

Research output: Contribution to journal › Article › peer-review

Abstract

We present an additional case of focal myositis which, after surgical excision of the muscular mass, did not evolve to generalized polymyositis. To our knowledge immunological evaluations of this disease have never before been carried out. Immunohistochemical analysis of the muscular mass showed the presence of activated endothelial cells, CD4 and macrophage cells in the perivascular and endomysial areas, suggesting an immune-mediated mechanism of muscular damage. At the same time the normal distribution of the peripheral blood lymphocyte subpopulations and the normal levels of serum IL-1β, IL-6, TNF-α, soluble IL-2R and soluble CD8 underline the non-systemic nature of the disease.

Original language	English
Pages (from-to)	753-757
Number of pages	5
Journal	Clinical and Experimental Rheumatology
Volume	13
Issue number	6
Publication status	Published - 1995

Keywords

focal myositis
immunohistochemical analysis

ASJC Scopus subject areas

Rheumatology
Immunology

Cite this

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abstract = "We present an additional case of focal myositis which, after surgical excision of the muscular mass, did not evolve to generalized polymyositis. To our knowledge immunological evaluations of this disease have never before been carried out. Immunohistochemical analysis of the muscular mass showed the presence of activated endothelial cells, CD4 and macrophage cells in the perivascular and endomysial areas, suggesting an immune-mediated mechanism of muscular damage. At the same time the normal distribution of the peripheral blood lymphocyte subpopulations and the normal levels of serum IL-1β, IL-6, TNF-α, soluble IL-2R and soluble CD8 underline the non-systemic nature of the disease.",

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T1 - Immunohistochemical analysis of an additional case of focal myositis

AU - Macchioni, P.

AU - Boiardi, L.

AU - Meliconi, R.

AU - Salvarani, C.

AU - Pulsatelli, L.

AU - Mancini, R.

AU - Prandi, S.

AU - Facchini, A.

AU - Portioli, I.

PY - 1995

Y1 - 1995

N2 - We present an additional case of focal myositis which, after surgical excision of the muscular mass, did not evolve to generalized polymyositis. To our knowledge immunological evaluations of this disease have never before been carried out. Immunohistochemical analysis of the muscular mass showed the presence of activated endothelial cells, CD4 and macrophage cells in the perivascular and endomysial areas, suggesting an immune-mediated mechanism of muscular damage. At the same time the normal distribution of the peripheral blood lymphocyte subpopulations and the normal levels of serum IL-1β, IL-6, TNF-α, soluble IL-2R and soluble CD8 underline the non-systemic nature of the disease.

AB - We present an additional case of focal myositis which, after surgical excision of the muscular mass, did not evolve to generalized polymyositis. To our knowledge immunological evaluations of this disease have never before been carried out. Immunohistochemical analysis of the muscular mass showed the presence of activated endothelial cells, CD4 and macrophage cells in the perivascular and endomysial areas, suggesting an immune-mediated mechanism of muscular damage. At the same time the normal distribution of the peripheral blood lymphocyte subpopulations and the normal levels of serum IL-1β, IL-6, TNF-α, soluble IL-2R and soluble CD8 underline the non-systemic nature of the disease.

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Immunohistochemical analysis of an additional case of focal myositis

Abstract

Keywords

ASJC Scopus subject areas

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