Immunohistochemical Biomarkers as a Surrogate of Molecular Analysis in Ovarian Carcinomas: A Review of the Literature

Giacomo Santandrea, Simonetta Piana, Riccardo Valli, Magda Zanelli, Elisa Gasparini, Antonio de Leo, Vincenzo Dario Mandato, Andrea Palicelli

Research output: Contribution to journalReview articlepeer-review

Abstract

The term “ovarian carcinoma” encompasses at least five different malignant neoplasms: high-grade serous carcinoma, low-grade serous carcinoma, endometrioid carcinoma, mucinous carcinoma, and clear cell carcinoma. These five histotypes demonstrated distinctive histological, molecular, and clinical features. The rise of novel target therapies and of a tailored oncological approach has demanded an integrated multidisciplinary approach in the setting of ovarian carcinoma. The need to implement a molecular-based classification in the worldwide diagnostic and therapeutic setting of ovarian cancer demanded a search for easy-to-use and cost-effective molecular-surrogate biomarkers, relying particularly on immunohistochemical analysis. The present review focuses on the role of immunohistochemistry as a surrogate of molecular analysis in the everyday diagnostic approach to ovarian carcinomas.

Original languageEnglish
Article number199
JournalDiagnostics
Volume11
Issue number2
DOIs
Publication statusPublished - Feb 2021

Keywords

  • Biomarkers
  • Immunohistochemistry
  • Molecular classification
  • Ovarian cancer

ASJC Scopus subject areas

  • Clinical Biochemistry

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