Abstract
Squamous cell carcinoma of the mammary gland is rare in both veterinary and human medicine. Whereas human metaplastic and squamous variants are known, the objectives of the current study were to ascertain the presence of such entities in canine mammary tumors and to distinguish them from other (epidermal, sweat gland) squamous tumors that may develop in the same area. A panel of antibodies (anti-cytokeratin [CK] 19, CK 14, CK 5/6, pancytokeratin, and vimentin) was used on 18 mammary gland malignancies with squamous features and 16 malignant skin tumors (11 squamous cell carcinomas of the skin and 5 sweat glands). Fifteen of the 18 mammary carcinomas were classified as metaplastic carcinomas, and the remaining 3 were classified as squamous cell carcinomas. The 2 most useful markers to establish the histogenesis of mammary tumors were pancytokeratin and CK 19. All other antibodies were equally expressed (CK 14 and 5/6) in all histotypes. The antibody panel discriminated primary epidermal squamous tumors (pancytokeratin positive and CK 19 negative) from gland-derived squamous neoplasms (pancytokeratin positive and CK 19 positive) but failed to distinguish primary mammary tumors from other squamous tumors of glandular origin.
| Original language | English |
|---|---|
| Pages (from-to) | 766-773 |
| Number of pages | 8 |
| Journal | Journal of Veterinary Diagnostic Investigation |
| Volume | 20 |
| Issue number | 6 |
| Publication status | Published - Nov 1 2008 |
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Keywords
- Cytokeratin 19
- Dogs
- Immunohistochemistry
- Mammary gland
- Pancytokeratin
- Squamous cell carcinoma
ASJC Scopus subject areas
- veterinary(all)
Cite this
Immunohistochemical characterization of mammary squamous cell carcinoma of the dog. / Sassi, Francesco; Sarli, Giuseppe; Brunetti, Barbara; Morandi, Federico; Benazzi, Cinzia.
In: Journal of Veterinary Diagnostic Investigation, Vol. 20, No. 6, 01.11.2008, p. 766-773.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunohistochemical characterization of mammary squamous cell carcinoma of the dog
AU - Sassi, Francesco
AU - Sarli, Giuseppe
AU - Brunetti, Barbara
AU - Morandi, Federico
AU - Benazzi, Cinzia
PY - 2008/11/1
Y1 - 2008/11/1
N2 - Squamous cell carcinoma of the mammary gland is rare in both veterinary and human medicine. Whereas human metaplastic and squamous variants are known, the objectives of the current study were to ascertain the presence of such entities in canine mammary tumors and to distinguish them from other (epidermal, sweat gland) squamous tumors that may develop in the same area. A panel of antibodies (anti-cytokeratin [CK] 19, CK 14, CK 5/6, pancytokeratin, and vimentin) was used on 18 mammary gland malignancies with squamous features and 16 malignant skin tumors (11 squamous cell carcinomas of the skin and 5 sweat glands). Fifteen of the 18 mammary carcinomas were classified as metaplastic carcinomas, and the remaining 3 were classified as squamous cell carcinomas. The 2 most useful markers to establish the histogenesis of mammary tumors were pancytokeratin and CK 19. All other antibodies were equally expressed (CK 14 and 5/6) in all histotypes. The antibody panel discriminated primary epidermal squamous tumors (pancytokeratin positive and CK 19 negative) from gland-derived squamous neoplasms (pancytokeratin positive and CK 19 positive) but failed to distinguish primary mammary tumors from other squamous tumors of glandular origin.
AB - Squamous cell carcinoma of the mammary gland is rare in both veterinary and human medicine. Whereas human metaplastic and squamous variants are known, the objectives of the current study were to ascertain the presence of such entities in canine mammary tumors and to distinguish them from other (epidermal, sweat gland) squamous tumors that may develop in the same area. A panel of antibodies (anti-cytokeratin [CK] 19, CK 14, CK 5/6, pancytokeratin, and vimentin) was used on 18 mammary gland malignancies with squamous features and 16 malignant skin tumors (11 squamous cell carcinomas of the skin and 5 sweat glands). Fifteen of the 18 mammary carcinomas were classified as metaplastic carcinomas, and the remaining 3 were classified as squamous cell carcinomas. The 2 most useful markers to establish the histogenesis of mammary tumors were pancytokeratin and CK 19. All other antibodies were equally expressed (CK 14 and 5/6) in all histotypes. The antibody panel discriminated primary epidermal squamous tumors (pancytokeratin positive and CK 19 negative) from gland-derived squamous neoplasms (pancytokeratin positive and CK 19 positive) but failed to distinguish primary mammary tumors from other squamous tumors of glandular origin.
KW - Cytokeratin 19
KW - Dogs
KW - Immunohistochemistry
KW - Mammary gland
KW - Pancytokeratin
KW - Squamous cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=57749174674&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=57749174674&partnerID=8YFLogxK
M3 - Article
C2 - 18987226
AN - SCOPUS:57749174674
VL - 20
SP - 766
EP - 773
JO - Journal of Veterinary Diagnostic Investigation
JF - Journal of Veterinary Diagnostic Investigation
SN - 1040-6387
IS - 6
ER -