Immunohistochemical characterization of mammary squamous cell carcinoma of the dog

Francesco Sassi, Giuseppe Sarli, Barbara Brunetti, Federico Morandi, Cinzia Benazzi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Squamous cell carcinoma of the mammary gland is rare in both veterinary and human medicine. Whereas human metaplastic and squamous variants are known, the objectives of the current study were to ascertain the presence of such entities in canine mammary tumors and to distinguish them from other (epidermal, sweat gland) squamous tumors that may develop in the same area. A panel of antibodies (anti-cytokeratin [CK] 19, CK 14, CK 5/6, pancytokeratin, and vimentin) was used on 18 mammary gland malignancies with squamous features and 16 malignant skin tumors (11 squamous cell carcinomas of the skin and 5 sweat glands). Fifteen of the 18 mammary carcinomas were classified as metaplastic carcinomas, and the remaining 3 were classified as squamous cell carcinomas. The 2 most useful markers to establish the histogenesis of mammary tumors were pancytokeratin and CK 19. All other antibodies were equally expressed (CK 14 and 5/6) in all histotypes. The antibody panel discriminated primary epidermal squamous tumors (pancytokeratin positive and CK 19 negative) from gland-derived squamous neoplasms (pancytokeratin positive and CK 19 positive) but failed to distinguish primary mammary tumors from other squamous tumors of glandular origin.

Original languageEnglish
Pages (from-to)766-773
Number of pages8
JournalJournal of Veterinary Diagnostic Investigation
Volume20
Issue number6
Publication statusPublished - Nov 1 2008

Fingerprint

squamous cell carcinoma
breasts
Keratin-19
Squamous Cell Carcinoma
mammary neoplasms (animal)
Breast
Dogs
sweat glands
neoplasms
dogs
Keratin-14
mammary glands
Keratin-5
Breast Neoplasms
antibodies
Sweat Glands
Neoplasms
Human Mammary Glands
vimentin
Keratin-6

Keywords

  • Cytokeratin 19
  • Dogs
  • Immunohistochemistry
  • Mammary gland
  • Pancytokeratin
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Sassi, F., Sarli, G., Brunetti, B., Morandi, F., & Benazzi, C. (2008). Immunohistochemical characterization of mammary squamous cell carcinoma of the dog. Journal of Veterinary Diagnostic Investigation, 20(6), 766-773.

Immunohistochemical characterization of mammary squamous cell carcinoma of the dog. / Sassi, Francesco; Sarli, Giuseppe; Brunetti, Barbara; Morandi, Federico; Benazzi, Cinzia.

In: Journal of Veterinary Diagnostic Investigation, Vol. 20, No. 6, 01.11.2008, p. 766-773.

Research output: Contribution to journalArticle

Sassi, F, Sarli, G, Brunetti, B, Morandi, F & Benazzi, C 2008, 'Immunohistochemical characterization of mammary squamous cell carcinoma of the dog', Journal of Veterinary Diagnostic Investigation, vol. 20, no. 6, pp. 766-773.
Sassi, Francesco ; Sarli, Giuseppe ; Brunetti, Barbara ; Morandi, Federico ; Benazzi, Cinzia. / Immunohistochemical characterization of mammary squamous cell carcinoma of the dog. In: Journal of Veterinary Diagnostic Investigation. 2008 ; Vol. 20, No. 6. pp. 766-773.
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