Immunohistochemical demonstration of vimentin in human cerebral tumors

D. Schiffer, M. T. Giordana, A. Mauro, A. Migheli, I. Germano, G. Giaccone

Research output: Contribution to journalArticlepeer-review


The distribution of vimentin (VIM) has been histochemically investigated in 53 cerebral tumors and compared in gliomas to that of glial fibrillary acidic protein (GFAP). In gliomas VIM is less positive than GFAP, but shows the same distribution. It cannot be considered as indicating immaturity of glial tumor cells. VIM is also positive in glial processes of cerebellar pilocytic astrocytomas, in Schwann cells of neurinomas and in endothelial cells of all oncotypes. In medulloblastomas, VIM decorates reactive glia cells. A diffuse positive reaction has been observed in meningiomas. In hemangioblastomas, besides intervascular and endothelial cells, groups of polygonal cells are intensely positive for both VIM and GFAP. The interpretatiên of VIM in cerebral tumors is largely based on the distribution patterns of this intermediate filament in the developing CNS of rodents.

Original languageEnglish
Pages (from-to)209-219
Number of pages11
JournalActa Neuropathologica
Issue number3-4
Publication statusPublished - Sep 1986


  • Cerebral tumors
  • Immunohistochemistry
  • Vimentin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology


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