Immunohistochemical detection of Ym1/Ym2 chitinase-like lectins associated with hyalinosis and polypoid adenomas of the transitional epithelium in a mouse with acute myeloid leukemia

F. Marchesi, S. Minucci, P. G. Pelicci, A. Gobbi, E. Scanziani

Research output: Contribution to journalArticle

Abstract

An 8-month-old PML/RARα knock-in female mouse developed a promyelocytic-like myeloid leukemia with an expected latency. At necropsy, besides the typical findings associated with myeloid leukemia, a severe unilateral hydronephrosis was observed. By histopathologic examination, 2 polypoid adenomas arising from the transitional epithelium of the renal pelvis and ureter were detected. The epithelial cells of the polypoid adenomas showed accumulation of hyaline eosinophilic material within the cytoplasm. Large amounts of extracellular eosinophilic crystals were also associated with the transitional cell adenomas. Immunohistochemical analysis revealed that the eosinophilic intracytoplasmic material and the extracellular eosinophilic crystals were composed of Ym proteins. A unilateral hyaline droplet tubular nephropathy was associated with the myeloid leukemia. Expression of Ym proteins characterized both the neoplastic myeloid infiltrates and the tubular hyaline droplets. In the present PML/RARα knock-in female mouse, the accumulation of Ym proteins associated with the myeloid leukemia and with the polypoid adenomas of the transitional epithelium underlies 2 distinct pathogenetic mechanisms.

Original languageEnglish
Pages (from-to)773-776
Number of pages4
JournalVeterinary Pathology
Volume43
Issue number5
DOIs
Publication statusPublished - 2006

Keywords

  • Myeloid leukemia
  • Polypoid adenomas
  • Transitional epithelium
  • Ym proteins

ASJC Scopus subject areas

  • veterinary(all)

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