TY - JOUR
T1 - Immunohistochemical evaluation of microsatellite instability in resected colorectal liver metastases
T2 - a preliminary experience
AU - Matteo, Barabino
AU - Gaetano, Piccolo
AU - Delfina, Tosi
AU - Riccardo, Masserano
AU - Roberto, Santambrogio
AU - Guglielmo, Piozzi
AU - Claudia, Cigala
AU - Carmelo, Luigiano
AU - Carla, Codecà
AU - Daris, Ferrari
AU - Maria, Ierardi Anna
AU - Gaetano, Bulfamante
AU - Carrafiello, Gianpaolo
AU - Enrico, Opocher
PY - 2020/7/1
Y1 - 2020/7/1
N2 - In this retrospective study, we evaluated the predictive role of different immunohistochemical expression (IHC) of the mismatch repair proteins (MMR) in patients with colorectal liver metastasis (CRLM) submitted to liver resection. A total of 108 patients were retrieved, and 15 patients were excluded from the study because of the impossibility to obtain adequate formalin-fixed tissue blocks. The final analysis included 93 patients. Twenty-eight cases (30%) presented a no loss of expression or microsatellite stability (MSS) status, 59 cases (63%) showed a hybrid loss of expression, while 6 cases (7%) presented a complete loss of expression or microsatellite instability status (MSI). Patients with complete or hybrid loss of expression of MMR developed a high intra-hepatic recurrence rate compared to other ones (54% vs 21% OR of 4.278, 95% CI 1.53–11.93) (p = 0.004). The same difference in terms of liver recurrence has been found among patients with R0 resection (50% vs 17% OR of 0.2, 95% CI 0.06–0.65) (p = 0.005). However, there was no difference in terms of disease-free survival and overall survival. Complete or hybrid loss of expression of MMR could be considered a risk factor for intra-hepatic recurrences after liver resections for CRLM.
AB - In this retrospective study, we evaluated the predictive role of different immunohistochemical expression (IHC) of the mismatch repair proteins (MMR) in patients with colorectal liver metastasis (CRLM) submitted to liver resection. A total of 108 patients were retrieved, and 15 patients were excluded from the study because of the impossibility to obtain adequate formalin-fixed tissue blocks. The final analysis included 93 patients. Twenty-eight cases (30%) presented a no loss of expression or microsatellite stability (MSS) status, 59 cases (63%) showed a hybrid loss of expression, while 6 cases (7%) presented a complete loss of expression or microsatellite instability status (MSI). Patients with complete or hybrid loss of expression of MMR developed a high intra-hepatic recurrence rate compared to other ones (54% vs 21% OR of 4.278, 95% CI 1.53–11.93) (p = 0.004). The same difference in terms of liver recurrence has been found among patients with R0 resection (50% vs 17% OR of 0.2, 95% CI 0.06–0.65) (p = 0.005). However, there was no difference in terms of disease-free survival and overall survival. Complete or hybrid loss of expression of MMR could be considered a risk factor for intra-hepatic recurrences after liver resections for CRLM.
KW - Colorectal liver metastases
KW - Immunohistochemical evaluation
KW - Microsatellite instability
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U2 - 10.1007/s12032-020-01388-4
DO - 10.1007/s12032-020-01388-4
M3 - Article
AN - SCOPUS:85086590010
VL - 37
JO - Medical Oncology
JF - Medical Oncology
SN - 1357-0560
IS - 7
M1 - 63
ER -