Immunohistochemical evaluation of minichromosome maintenance protein 7 in astrocytoma grading

Angelica Facoetti, E. Ranza, I. Grecchi, E. Benericetti, M. Ceroni, P. Morbini, R. Nano

Research output: Contribution to journalArticlepeer-review

Abstract

The minichromosome maintenance (MCM) proteins, which play an important role in eukaryotic DNA replication, represent a group of proteins that are currently under investigation as novel diagnostic tumor markers. Several studies have proved a greater reliability of MCM proteins to stain proliferating cells compared to Ki67 protein, a routinely used proliferation marker in histopathology. In the present study, the expressions of MCM7 and Ki67 were estimated in 66 primary human astrocytomas in relation to tumor grade (Grade I-IV, WHO). MCM7 significantly stained more nuclei compared to Ki67 in all the histopathological grades investigated. In addition, a stronger increase of the MCM7 labelling index, in relation to the tumor aggressiveness, was observed.

Original languageEnglish
Pages (from-to)3513-3516
Number of pages4
JournalAnticancer Research
Volume26
Issue number5 A
Publication statusPublished - Sep 2006

Keywords

  • Astrocytoma
  • Grading
  • Ki67
  • MCM7
  • Proliferation markers

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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