Immunohistochemical evaluation of minichromosome maintenance protein 7 in astrocytoma grading

Angelica Facoetti, E. Ranza, I. Grecchi, E. Benericetti, M. Ceroni, P. Morbini, R. Nano

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The minichromosome maintenance (MCM) proteins, which play an important role in eukaryotic DNA replication, represent a group of proteins that are currently under investigation as novel diagnostic tumor markers. Several studies have proved a greater reliability of MCM proteins to stain proliferating cells compared to Ki67 protein, a routinely used proliferation marker in histopathology. In the present study, the expressions of MCM7 and Ki67 were estimated in 66 primary human astrocytomas in relation to tumor grade (Grade I-IV, WHO). MCM7 significantly stained more nuclei compared to Ki67 in all the histopathological grades investigated. In addition, a stronger increase of the MCM7 labelling index, in relation to the tumor aggressiveness, was observed.

Original languageEnglish
Pages (from-to)3513-3516
Number of pages4
JournalAnticancer Research
Volume26
Issue number5 A
Publication statusPublished - Sep 2006

Fingerprint

Minichromosome Maintenance Proteins
Astrocytoma
Tumor Biomarkers
DNA Replication
Neoplasms
Proteins
Coloring Agents

Keywords

  • Astrocytoma
  • Grading
  • Ki67
  • MCM7
  • Proliferation markers

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Facoetti, A., Ranza, E., Grecchi, I., Benericetti, E., Ceroni, M., Morbini, P., & Nano, R. (2006). Immunohistochemical evaluation of minichromosome maintenance protein 7 in astrocytoma grading. Anticancer Research, 26(5 A), 3513-3516.

Immunohistochemical evaluation of minichromosome maintenance protein 7 in astrocytoma grading. / Facoetti, Angelica; Ranza, E.; Grecchi, I.; Benericetti, E.; Ceroni, M.; Morbini, P.; Nano, R.

In: Anticancer Research, Vol. 26, No. 5 A, 09.2006, p. 3513-3516.

Research output: Contribution to journalArticle

Facoetti, A, Ranza, E, Grecchi, I, Benericetti, E, Ceroni, M, Morbini, P & Nano, R 2006, 'Immunohistochemical evaluation of minichromosome maintenance protein 7 in astrocytoma grading', Anticancer Research, vol. 26, no. 5 A, pp. 3513-3516.
Facoetti, Angelica ; Ranza, E. ; Grecchi, I. ; Benericetti, E. ; Ceroni, M. ; Morbini, P. ; Nano, R. / Immunohistochemical evaluation of minichromosome maintenance protein 7 in astrocytoma grading. In: Anticancer Research. 2006 ; Vol. 26, No. 5 A. pp. 3513-3516.
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