Background: Fatty Acid Synthase (FAS) and Human Erythrocyte Glucose Transponer 1 (GLUT1) are new markers involved in the biological activities of cancer cells. FAS is a multifunctional enzyme that synthesizes palmitate from acetyl-CoA and malonyl-CoA. GLUT1 is a transmembrane protein normally expressed in perineurium and erythrocytes-FAS and GLUT1 expression have been recently described in many aggressive tumors. We explored the immunohistochemical expression of FAS and GLUT1 in bladder carcinomas to reveal statistical associations with clinico-pathological features and recurrence. Materials and Methods: Thirty-one node-and distant metastasis-negative transitional cell carcinomas from patients with a five-year follow-up were evaluated for FAS and GLUT1 expression. Results: Univariate analysis showed that low-grade, pTa stage and FAS-negative expression were associated with indolent tumors. Multivariate analysis showed that FAS expression (p=0.006) and pT1-2 stage tumors (p=0.001) were independent predictors of recurrence. Conclusion: Endogenous fatty acids are an exploitable storage of energy for aggressive human bladder carcinomas. Glucose uptake is not required by bladder tumors.
|Number of pages||5|
|Issue number||1 A|
|Publication status||Published - Jan 2003|
ASJC Scopus subject areas
- Cancer Research