Abstract
The expression of the uncoupling protein (UCP), a protein unique to brown adipocyte mitochondria, was studied in sections of a human hibernoma by means of immunohistochemistry. Multilocular, but not unilocular, adipocytes expressed the UCP in the tissue. Further, the immunostaining was not uniform in multilocular cells, because small adipocytes with finely multivacuolar or scanty lipid deposit showed more intense staining. This pattern is similar to that found in brown adipose tissue. Ultrastructural investigation confirmed that a majority of proliferating cells had the morphological characteristics of brown adipocyte. Results indicate that adipocytes in hibernoma may be very close to brown adipocytes both morphologically and immunocytochemically.
| Original language | English |
|---|---|
| Pages (from-to) | 75-78 |
| Number of pages | 4 |
| Journal | Biology of the cell / under the auspices of the European Cell Biology Organization |
| Volume | 80 |
| Issue number | 1 |
| Publication status | Published - 1994 |
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Keywords
- brown adipose tissue
- hibernoma
- immunohistochemistry
- ultrastructure
ASJC Scopus subject areas
- Cell Biology
Cite this
Immunohistochemical identification of the uncoupling protein in human hibernoma. / Zancanaro, Carlo; Pelosi, Giuseppe; Accordini, Cristina; Balercia, Giancarlo; Sbabo, Laura; Cinti, Saverio.
In: Biology of the cell / under the auspices of the European Cell Biology Organization, Vol. 80, No. 1, 1994, p. 75-78.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunohistochemical identification of the uncoupling protein in human hibernoma
AU - Zancanaro, Carlo
AU - Pelosi, Giuseppe
AU - Accordini, Cristina
AU - Balercia, Giancarlo
AU - Sbabo, Laura
AU - Cinti, Saverio
PY - 1994
Y1 - 1994
N2 - The expression of the uncoupling protein (UCP), a protein unique to brown adipocyte mitochondria, was studied in sections of a human hibernoma by means of immunohistochemistry. Multilocular, but not unilocular, adipocytes expressed the UCP in the tissue. Further, the immunostaining was not uniform in multilocular cells, because small adipocytes with finely multivacuolar or scanty lipid deposit showed more intense staining. This pattern is similar to that found in brown adipose tissue. Ultrastructural investigation confirmed that a majority of proliferating cells had the morphological characteristics of brown adipocyte. Results indicate that adipocytes in hibernoma may be very close to brown adipocytes both morphologically and immunocytochemically.
AB - The expression of the uncoupling protein (UCP), a protein unique to brown adipocyte mitochondria, was studied in sections of a human hibernoma by means of immunohistochemistry. Multilocular, but not unilocular, adipocytes expressed the UCP in the tissue. Further, the immunostaining was not uniform in multilocular cells, because small adipocytes with finely multivacuolar or scanty lipid deposit showed more intense staining. This pattern is similar to that found in brown adipose tissue. Ultrastructural investigation confirmed that a majority of proliferating cells had the morphological characteristics of brown adipocyte. Results indicate that adipocytes in hibernoma may be very close to brown adipocytes both morphologically and immunocytochemically.
KW - brown adipose tissue
KW - hibernoma
KW - immunohistochemistry
KW - ultrastructure
UR - http://www.scopus.com/inward/record.url?scp=0028214269&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028214269&partnerID=8YFLogxK
M3 - Article
C2 - 8054887
AN - SCOPUS:0028214269
VL - 80
SP - 75
EP - 78
JO - Biology of the Cell
JF - Biology of the Cell
SN - 0248-4900
IS - 1
ER -