Immunohistochemical localization of epidermal growth factor receptor in leiomyomas from women treated with goserelin depot

M. Leone, S. Cucuccio, P. L. Venturini, M. Valenzano Menada, M. Messeni Leone, L. De Cecco

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Epidermal growth factor receptors (EGFr) were studied by immunohistochemistry in human myometrium and leiomyomas from women treated with the GnRH agonist (GnRH-a) goserelin. The results were compared with those obtained from women not treated. Vessel cells of leiomyomas and myometrium were always more immunoreactive than fibrocytes and myocits. In fibroids from treated patients the histochemical (HSCORE) of vessel cells was always significantly lower (p <0.001) than in control patients. Our data confirm a role of EGF also in fibroid growth and suggest that, the blood supply reduction associated with the volume reduction of these tumours, consequent to the GnRH-a treatment, could be EGF mediated.

Original languageEnglish
Pages (from-to)442-445
Number of pages4
JournalHormone and Metabolic Research
Volume23
Issue number9
Publication statusPublished - 1991

Fingerprint

Goserelin
Leiomyoma
Epidermal Growth Factor Receptor
Epidermal Growth Factor
Gonadotropin-Releasing Hormone
Myometrium
Tumors
Blood
Tumor Burden
Immunohistochemistry
Growth

Keywords

  • Angiogenesis
  • EGF
  • Fibroids
  • GnRH agonist

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Leone, M., Cucuccio, S., Venturini, P. L., Valenzano Menada, M., Messeni Leone, M., & De Cecco, L. (1991). Immunohistochemical localization of epidermal growth factor receptor in leiomyomas from women treated with goserelin depot. Hormone and Metabolic Research, 23(9), 442-445.

Immunohistochemical localization of epidermal growth factor receptor in leiomyomas from women treated with goserelin depot. / Leone, M.; Cucuccio, S.; Venturini, P. L.; Valenzano Menada, M.; Messeni Leone, M.; De Cecco, L.

In: Hormone and Metabolic Research, Vol. 23, No. 9, 1991, p. 442-445.

Research output: Contribution to journalArticle

Leone, M, Cucuccio, S, Venturini, PL, Valenzano Menada, M, Messeni Leone, M & De Cecco, L 1991, 'Immunohistochemical localization of epidermal growth factor receptor in leiomyomas from women treated with goserelin depot', Hormone and Metabolic Research, vol. 23, no. 9, pp. 442-445.
Leone M, Cucuccio S, Venturini PL, Valenzano Menada M, Messeni Leone M, De Cecco L. Immunohistochemical localization of epidermal growth factor receptor in leiomyomas from women treated with goserelin depot. Hormone and Metabolic Research. 1991;23(9):442-445.
Leone, M. ; Cucuccio, S. ; Venturini, P. L. ; Valenzano Menada, M. ; Messeni Leone, M. ; De Cecco, L. / Immunohistochemical localization of epidermal growth factor receptor in leiomyomas from women treated with goserelin depot. In: Hormone and Metabolic Research. 1991 ; Vol. 23, No. 9. pp. 442-445.
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