Epidermal growth factor receptors (EGFr) were studied by immunohistochemistry in human myometrium and leiomyomas from women treated with the GnRH agonist (GnRH-a) goserelin. The results were compared with those obtained from women not treated. Vessel cells of leiomyomas and myometrium were always more immunoreactive than fibrocytes and myocits. In fibroids from treated patients the histochemical (HSCORE) of vessel cells was always significantly lower (p <0.001) than in control patients. Our data confirm a role of EGF also in fibroid growth and suggest that, the blood supply reduction associated with the volume reduction of these tumours, consequent to the GnRH-a treatment, could be EGF mediated.
|Number of pages||4|
|Journal||Hormone and Metabolic Research|
|Publication status||Published - 1991|
- GnRH agonist
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