Abstract
Epidermal growth factor receptors (EGFr) were studied by immunohistochemistry in human myometrium and leiomyomas from women treated with the GnRH agonist (GnRH-a) goserelin. The results were compared with those obtained from women not treated. Vessel cells of leiomyomas and myometrium were always more immunoreactive than fibrocytes and myocits. In fibroids from treated patients the histochemical (HSCORE) of vessel cells was always significantly lower (p <0.001) than in control patients. Our data confirm a role of EGF also in fibroid growth and suggest that, the blood supply reduction associated with the volume reduction of these tumours, consequent to the GnRH-a treatment, could be EGF mediated.
| Original language | English |
|---|---|
| Pages (from-to) | 442-445 |
| Number of pages | 4 |
| Journal | Hormone and Metabolic Research |
| Volume | 23 |
| Issue number | 9 |
| Publication status | Published - 1991 |
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Keywords
- Angiogenesis
- EGF
- Fibroids
- GnRH agonist
ASJC Scopus subject areas
- Biochemistry
- Endocrinology
Cite this
Immunohistochemical localization of epidermal growth factor receptor in leiomyomas from women treated with goserelin depot. / Leone, M.; Cucuccio, S.; Venturini, P. L.; Valenzano Menada, M.; Messeni Leone, M.; De Cecco, L.
In: Hormone and Metabolic Research, Vol. 23, No. 9, 1991, p. 442-445.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunohistochemical localization of epidermal growth factor receptor in leiomyomas from women treated with goserelin depot
AU - Leone, M.
AU - Cucuccio, S.
AU - Venturini, P. L.
AU - Valenzano Menada, M.
AU - Messeni Leone, M.
AU - De Cecco, L.
PY - 1991
Y1 - 1991
N2 - Epidermal growth factor receptors (EGFr) were studied by immunohistochemistry in human myometrium and leiomyomas from women treated with the GnRH agonist (GnRH-a) goserelin. The results were compared with those obtained from women not treated. Vessel cells of leiomyomas and myometrium were always more immunoreactive than fibrocytes and myocits. In fibroids from treated patients the histochemical (HSCORE) of vessel cells was always significantly lower (p <0.001) than in control patients. Our data confirm a role of EGF also in fibroid growth and suggest that, the blood supply reduction associated with the volume reduction of these tumours, consequent to the GnRH-a treatment, could be EGF mediated.
AB - Epidermal growth factor receptors (EGFr) were studied by immunohistochemistry in human myometrium and leiomyomas from women treated with the GnRH agonist (GnRH-a) goserelin. The results were compared with those obtained from women not treated. Vessel cells of leiomyomas and myometrium were always more immunoreactive than fibrocytes and myocits. In fibroids from treated patients the histochemical (HSCORE) of vessel cells was always significantly lower (p <0.001) than in control patients. Our data confirm a role of EGF also in fibroid growth and suggest that, the blood supply reduction associated with the volume reduction of these tumours, consequent to the GnRH-a treatment, could be EGF mediated.
KW - Angiogenesis
KW - EGF
KW - Fibroids
KW - GnRH agonist
UR - http://www.scopus.com/inward/record.url?scp=0025896387&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025896387&partnerID=8YFLogxK
M3 - Article
C2 - 1835956
AN - SCOPUS:0025896387
VL - 23
SP - 442
EP - 445
JO - Hormone and Metabolic Research
JF - Hormone and Metabolic Research
SN - 0018-5043
IS - 9
ER -