Immunohistochemical localization of epidermal growth factor receptor in leiomyomas from women treated with goserelin depot

M. Leone, S. Cucuccio, P. L. Venturini, M. Valenzano Menada, M. Messeni Leone, L. De Cecco

Research output: Contribution to journalArticlepeer-review

Abstract

Epidermal growth factor receptors (EGFr) were studied by immunohistochemistry in human myometrium and leiomyomas from women treated with the GnRH agonist (GnRH-a) goserelin. The results were compared with those obtained from women not treated. Vessel cells of leiomyomas and myometrium were always more immunoreactive than fibrocytes and myocits. In fibroids from treated patients the histochemical (HSCORE) of vessel cells was always significantly lower (p <0.001) than in control patients. Our data confirm a role of EGF also in fibroid growth and suggest that, the blood supply reduction associated with the volume reduction of these tumours, consequent to the GnRH-a treatment, could be EGF mediated.

Original languageEnglish
Pages (from-to)442-445
Number of pages4
JournalHormone and Metabolic Research
Volume23
Issue number9
Publication statusPublished - 1991

Keywords

  • Angiogenesis
  • EGF
  • Fibroids
  • GnRH agonist

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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