Immunohistochemical localization of epidermal growth factor receptor in leiomyomas from women treated with goserelin depot

M. Leone; S. Cucuccio; P. L. Venturini; M. Valenzano Menada; M. Messeni Leone; L. De Cecco

Immunohistochemical localization of epidermal growth factor receptor in leiomyomas from women treated with goserelin depot

M. Leone, S. Cucuccio, P. L. Venturini, M. Valenzano Menada, M. Messeni Leone, L. De Cecco

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

Epidermal growth factor receptors (EGFr) were studied by immunohistochemistry in human myometrium and leiomyomas from women treated with the GnRH agonist (GnRH-a) goserelin. The results were compared with those obtained from women not treated. Vessel cells of leiomyomas and myometrium were always more immunoreactive than fibrocytes and myocits. In fibroids from treated patients the histochemical (HSCORE) of vessel cells was always significantly lower (p <0.001) than in control patients. Our data confirm a role of EGF also in fibroid growth and suggest that, the blood supply reduction associated with the volume reduction of these tumours, consequent to the GnRH-a treatment, could be EGF mediated.

Original language	English
Pages (from-to)	442-445
Number of pages	4
Journal	Hormone and Metabolic Research
Volume	23
Issue number	9
Publication status	Published - 1991

Keywords

Angiogenesis
EGF
Fibroids
GnRH agonist

ASJC Scopus subject areas

Biochemistry
Endocrinology

Cite this

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title = "Immunohistochemical localization of epidermal growth factor receptor in leiomyomas from women treated with goserelin depot",

abstract = "Epidermal growth factor receptors (EGFr) were studied by immunohistochemistry in human myometrium and leiomyomas from women treated with the GnRH agonist (GnRH-a) goserelin. The results were compared with those obtained from women not treated. Vessel cells of leiomyomas and myometrium were always more immunoreactive than fibrocytes and myocits. In fibroids from treated patients the histochemical (HSCORE) of vessel cells was always significantly lower (p <0.001) than in control patients. Our data confirm a role of EGF also in fibroid growth and suggest that, the blood supply reduction associated with the volume reduction of these tumours, consequent to the GnRH-a treatment, could be EGF mediated.",

keywords = "Angiogenesis, EGF, Fibroids, GnRH agonist",

author = "M. Leone and S. Cucuccio and Venturini, {P. L.} and {Valenzano Menada}, M. and {Messeni Leone}, M. and {De Cecco}, L.",

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journal = "Hormone and Metabolic Research",

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AU - Leone, M.

AU - Cucuccio, S.

AU - Venturini, P. L.

AU - Valenzano Menada, M.

AU - Messeni Leone, M.

AU - De Cecco, L.

PY - 1991

Y1 - 1991

N2 - Epidermal growth factor receptors (EGFr) were studied by immunohistochemistry in human myometrium and leiomyomas from women treated with the GnRH agonist (GnRH-a) goserelin. The results were compared with those obtained from women not treated. Vessel cells of leiomyomas and myometrium were always more immunoreactive than fibrocytes and myocits. In fibroids from treated patients the histochemical (HSCORE) of vessel cells was always significantly lower (p <0.001) than in control patients. Our data confirm a role of EGF also in fibroid growth and suggest that, the blood supply reduction associated with the volume reduction of these tumours, consequent to the GnRH-a treatment, could be EGF mediated.

AB - Epidermal growth factor receptors (EGFr) were studied by immunohistochemistry in human myometrium and leiomyomas from women treated with the GnRH agonist (GnRH-a) goserelin. The results were compared with those obtained from women not treated. Vessel cells of leiomyomas and myometrium were always more immunoreactive than fibrocytes and myocits. In fibroids from treated patients the histochemical (HSCORE) of vessel cells was always significantly lower (p <0.001) than in control patients. Our data confirm a role of EGF also in fibroid growth and suggest that, the blood supply reduction associated with the volume reduction of these tumours, consequent to the GnRH-a treatment, could be EGF mediated.

KW - Angiogenesis

KW - EGF

KW - Fibroids

KW - GnRH agonist

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Immunohistochemical localization of epidermal growth factor receptor in leiomyomas from women treated with goserelin depot

Abstract

Keywords

ASJC Scopus subject areas

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