Immunohistochemical reactivity of anti-LAV p18 monoclonal antibody in lymph nodes from PGL and AIDS patients.

C. L. Parravicini; L. Vago; G. C. Costanzi; J. C. Gluckman; D. Klatzmann; E. Berti; F. Barre-Sinoussi; J. C. Chermann; A. Lazzarin; M. Moroni

Immunohistochemical reactivity of anti-LAV p18 monoclonal antibody in lymph nodes from PGL and AIDS patients.

C. L. Parravicini, L. Vago, G. C. Costanzi, J. C. Gluckman, D. Klatzmann, E. Berti, F. Barre-Sinoussi, J. C. Chermann, A. Lazzarin, M. Moroni

Research output: Contribution to journal › Article › peer-review

Abstract

This study deals with the immunohistochemistry of a monoclonal antibody (Mab) raised against the p18 protein of the LAV virus in lymphnodes from 20 cases of persistent generalized lymphoadenopathy (PGL) (2) and 6 of acquired immunodeficiency syndrome (AIDS) (3). In all the PGL cases that have been studied, we observed a very important disruption of the follicular dendritic cell's (FDC) framework in the germinal centers which is associated with the presence of an increased number of Leu2a+ lymphocytes inside the germinal centers. This observation is consistent with the main morphological feature of the lymphnodes in the PGL syndrome which is mainly characterized by lesions of FD cells.

Original language	English
Pages (from-to)	422-424
Number of pages	3
Journal	Bollettino dell'Istituto Sieroterapico Milanese
Volume	64
Issue number	5
Publication status	Published - 1985

ASJC Scopus subject areas

Immunology

Cite this

@article{e2aa11c92860490884db98f6d21186f9,

title = "Immunohistochemical reactivity of anti-LAV p18 monoclonal antibody in lymph nodes from PGL and AIDS patients.",

abstract = "This study deals with the immunohistochemistry of a monoclonal antibody (Mab) raised against the p18 protein of the LAV virus in lymphnodes from 20 cases of persistent generalized lymphoadenopathy (PGL) (2) and 6 of acquired immunodeficiency syndrome (AIDS) (3). In all the PGL cases that have been studied, we observed a very important disruption of the follicular dendritic cell's (FDC) framework in the germinal centers which is associated with the presence of an increased number of Leu2a+ lymphocytes inside the germinal centers. This observation is consistent with the main morphological feature of the lymphnodes in the PGL syndrome which is mainly characterized by lesions of FD cells.",

author = "Parravicini, {C. L.} and L. Vago and Costanzi, {G. C.} and Gluckman, {J. C.} and D. Klatzmann and E. Berti and F. Barre-Sinoussi and Chermann, {J. C.} and A. Lazzarin and M. Moroni",

year = "1985",

language = "English",

volume = "64",

pages = "422--424",

journal = "Bollettino dell'Istituto Sieroterapico Milanese",

issn = "0021-2547",

number = "5",

}

TY - JOUR

T1 - Immunohistochemical reactivity of anti-LAV p18 monoclonal antibody in lymph nodes from PGL and AIDS patients.

AU - Parravicini, C. L.

AU - Vago, L.

AU - Costanzi, G. C.

AU - Gluckman, J. C.

AU - Klatzmann, D.

AU - Berti, E.

AU - Barre-Sinoussi, F.

AU - Chermann, J. C.

AU - Lazzarin, A.

AU - Moroni, M.

PY - 1985

Y1 - 1985

N2 - This study deals with the immunohistochemistry of a monoclonal antibody (Mab) raised against the p18 protein of the LAV virus in lymphnodes from 20 cases of persistent generalized lymphoadenopathy (PGL) (2) and 6 of acquired immunodeficiency syndrome (AIDS) (3). In all the PGL cases that have been studied, we observed a very important disruption of the follicular dendritic cell's (FDC) framework in the germinal centers which is associated with the presence of an increased number of Leu2a+ lymphocytes inside the germinal centers. This observation is consistent with the main morphological feature of the lymphnodes in the PGL syndrome which is mainly characterized by lesions of FD cells.

AB - This study deals with the immunohistochemistry of a monoclonal antibody (Mab) raised against the p18 protein of the LAV virus in lymphnodes from 20 cases of persistent generalized lymphoadenopathy (PGL) (2) and 6 of acquired immunodeficiency syndrome (AIDS) (3). In all the PGL cases that have been studied, we observed a very important disruption of the follicular dendritic cell's (FDC) framework in the germinal centers which is associated with the presence of an increased number of Leu2a+ lymphocytes inside the germinal centers. This observation is consistent with the main morphological feature of the lymphnodes in the PGL syndrome which is mainly characterized by lesions of FD cells.

UR - http://www.scopus.com/inward/record.url?scp=0022322537&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022322537&partnerID=8YFLogxK

M3 - Article

C2 - 3004544

AN - SCOPUS:0022322537

VL - 64

SP - 422

EP - 424

JO - Bollettino dell'Istituto Sieroterapico Milanese

JF - Bollettino dell'Istituto Sieroterapico Milanese

SN - 0021-2547

IS - 5

ER -

Immunohistochemical reactivity of anti-LAV p18 monoclonal antibody in lymph nodes from PGL and AIDS patients.

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this