Abstract
This study deals with the immunohistochemistry of a monoclonal antibody (Mab) raised against the p18 protein of the LAV virus in lymphnodes from 20 cases of persistent generalized lymphoadenopathy (PGL) (2) and 6 of acquired immunodeficiency syndrome (AIDS) (3). In all the PGL cases that have been studied, we observed a very important disruption of the follicular dendritic cell's (FDC) framework in the germinal centers which is associated with the presence of an increased number of Leu2a+ lymphocytes inside the germinal centers. This observation is consistent with the main morphological feature of the lymphnodes in the PGL syndrome which is mainly characterized by lesions of FD cells.
| Original language | English |
|---|---|
| Pages (from-to) | 422-424 |
| Number of pages | 3 |
| Journal | Bollettino dell'Istituto Sieroterapico Milanese |
| Volume | 64 |
| Issue number | 5 |
| Publication status | Published - 1985 |
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ASJC Scopus subject areas
- Immunology
Cite this
Parravicini, C. L., Vago, L., Costanzi, G. C., Gluckman, J. C., Klatzmann, D., Berti, E., Barre-Sinoussi, F., Chermann, J. C., Lazzarin, A., & Moroni, M. (1985). Immunohistochemical reactivity of anti-LAV p18 monoclonal antibody in lymph nodes from PGL and AIDS patients. Bollettino dell'Istituto Sieroterapico Milanese, 64(5), 422-424.