Immunohistochemical study of carcinoembryonic antigen, epithelial membrane antigen, and secretory immunoglobulin system in the large bowel adenoma-carcinoma sequence.

G. Lapertosa, P. Baracchini, E. Fulcheri, R. Tanzi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

To identify parameters for the malignant potential of large bowel adenomas, we used the avidin-biotin-peroxidase complex (ABC) technique. Patterns of carcinoembryonic antigen, epithelial membrane antigen, IgAs, and secretory component in 31 tubular, tubulovillous, and villous adenomas with different grading of dysplasia (mild, moderate, severe) and with early cancer were studied. All markers showed different degrees of staining intensity and various cellular localizations. We found that these variations might be related to dysplasia grading. Adenoma size did not influence the marker patterns. IgAs seemed to be the more selective among the markers studied. Our results suggested a dysplasia-carcinoma sequence instead of an adenoma-carcinoma sequence concept.

Original languageEnglish
Pages (from-to)469-476
Number of pages8
JournalCancer Detection and Prevention
Volume9
Issue number5-6
Publication statusPublished - 1986

Fingerprint

Mucin-1
Carcinoembryonic Antigen
Adenoma
Immunoglobulins
Carcinoma
Villous Adenoma
Secretory Component
Avidin
Biotin
Peroxidase
Staining and Labeling
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

@article{1bb63044fc0642e08fe7ebfe57506966,
title = "Immunohistochemical study of carcinoembryonic antigen, epithelial membrane antigen, and secretory immunoglobulin system in the large bowel adenoma-carcinoma sequence.",
abstract = "To identify parameters for the malignant potential of large bowel adenomas, we used the avidin-biotin-peroxidase complex (ABC) technique. Patterns of carcinoembryonic antigen, epithelial membrane antigen, IgAs, and secretory component in 31 tubular, tubulovillous, and villous adenomas with different grading of dysplasia (mild, moderate, severe) and with early cancer were studied. All markers showed different degrees of staining intensity and various cellular localizations. We found that these variations might be related to dysplasia grading. Adenoma size did not influence the marker patterns. IgAs seemed to be the more selective among the markers studied. Our results suggested a dysplasia-carcinoma sequence instead of an adenoma-carcinoma sequence concept.",
author = "G. Lapertosa and P. Baracchini and E. Fulcheri and R. Tanzi",
year = "1986",
language = "English",
volume = "9",
pages = "469--476",
journal = "Cancer Detection and Prevention",
issn = "0361-090X",
publisher = "Elsevier BV",
number = "5-6",

}

TY - JOUR

T1 - Immunohistochemical study of carcinoembryonic antigen, epithelial membrane antigen, and secretory immunoglobulin system in the large bowel adenoma-carcinoma sequence.

AU - Lapertosa, G.

AU - Baracchini, P.

AU - Fulcheri, E.

AU - Tanzi, R.

PY - 1986

Y1 - 1986

N2 - To identify parameters for the malignant potential of large bowel adenomas, we used the avidin-biotin-peroxidase complex (ABC) technique. Patterns of carcinoembryonic antigen, epithelial membrane antigen, IgAs, and secretory component in 31 tubular, tubulovillous, and villous adenomas with different grading of dysplasia (mild, moderate, severe) and with early cancer were studied. All markers showed different degrees of staining intensity and various cellular localizations. We found that these variations might be related to dysplasia grading. Adenoma size did not influence the marker patterns. IgAs seemed to be the more selective among the markers studied. Our results suggested a dysplasia-carcinoma sequence instead of an adenoma-carcinoma sequence concept.

AB - To identify parameters for the malignant potential of large bowel adenomas, we used the avidin-biotin-peroxidase complex (ABC) technique. Patterns of carcinoembryonic antigen, epithelial membrane antigen, IgAs, and secretory component in 31 tubular, tubulovillous, and villous adenomas with different grading of dysplasia (mild, moderate, severe) and with early cancer were studied. All markers showed different degrees of staining intensity and various cellular localizations. We found that these variations might be related to dysplasia grading. Adenoma size did not influence the marker patterns. IgAs seemed to be the more selective among the markers studied. Our results suggested a dysplasia-carcinoma sequence instead of an adenoma-carcinoma sequence concept.

UR - http://www.scopus.com/inward/record.url?scp=0022988623&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022988623&partnerID=8YFLogxK

M3 - Article

C2 - 3536092

AN - SCOPUS:0022988623

VL - 9

SP - 469

EP - 476

JO - Cancer Detection and Prevention

JF - Cancer Detection and Prevention

SN - 0361-090X

IS - 5-6

ER -