Immunohistochemical study of fatty acid synthase, Ki67, proliferating cell nuclear antigen, and p53 expression in hyperplastic parathyroids.

P. L. Alò, P. Visca, S. Mazzaferro, D. E. Serpieri, A. Mangoni, C. Botti, S. Monaco, M. Carboni, F. Zaraca, G. Trombetta, U. Di Tondo

Research output: Contribution to journalArticlepeer-review

Abstract

Patients with secondary hyperparathyroidism following chronic renal disease frequently develop hyperplastic parathyroids. Hyperplastic parathyroids have an increased number of chief cells, a decreased amount of stromal fat, and a nodular or diffuse histologic pattern. Hyperplastic parathyroids may also express higher proliferative activity compared with controls. We evaluated the morphologic features and immunohistochemical expression of fatty acid synthase (FAS), Ki67, proliferating cell nuclear antigen, and p53 protein in 78 hyperplastic parathyroids from 20 patients with secondary hyperparathyroidism. Twenty normal parathyroids incidentally removed during nonneoplastic thyroid surgery were used as controls. Our results showed that hyperplastic glands overexpress FAS (P =.06). Statistical analysis also revealed a significant association between FAS and p53 protein (P =.006) and between FAS and hyperplastic glands with a predominant nodular pattern (P =.02). Hyperplastic parathyroids from patients with chronic renal failure strongly express FAS. Fatty acid synthase may therefore be a potential biological indicator of highly proliferating parathyroid cells.

Original languageEnglish
Pages (from-to)287-293
Number of pages7
JournalAnnals of Diagnostic Pathology
Volume3
Issue number5
Publication statusPublished - Oct 1999

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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