Immunohistochemistry with antibodies to hepatocyte growth factor and its receptor protein (c-MET) in human brain tissues

T. Yamada, H. Tsubouchi, Y. Daikuhara, M. Prat, P. M. Comoglio, P. L. McGeer, E. G. McGeer

Research output: Contribution to journalArticlepeer-review

Abstract

Hepatocyte growth factor (HGF) is a potent mitogen for mature hepatocytes, and also has multifunctional effects on some other cells in various organs. The human c-Met proto-oncogene product has recently been identified as its high-affinity receptor. We examined HGF-like and c-Met protein-like immunoreactivities in the brains of neurologically normal, lacunar stroke and Alzheimer disease (AD) cases. The HGF antibody stained only round cells in the capillaries and astrocytes in the white matter. Positive staining with the antibody to c-Met protein was seen in microglia, predominantly in the white matter. The possibility of interactions between astrocytes and microglia through HGF and its receptor is suggested.

Original languageEnglish
Pages (from-to)308-312
Number of pages5
JournalBrain Research
Volume637
Issue number1-2
DOIs
Publication statusPublished - Feb 21 1994

Keywords

  • Alzheimer's disease
  • Astrocyte
  • c-Met protein
  • Hepatocytes growth factor
  • Microglia

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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