Immunohistochemistry with antibodies to hepatocyte growth factor and its receptor protein (c-MET) in human brain tissues

T. Yamada; H. Tsubouchi; Y. Daikuhara; M. Prat; P. M. Comoglio; P. L. McGeer; E. G. McGeer

doi:10.1016/0006-8993(94)91250-5

Immunohistochemistry with antibodies to hepatocyte growth factor and its receptor protein (c-MET) in human brain tissues

T. Yamada, H. Tsubouchi, Y. Daikuhara, M. Prat, P. M. Comoglio, P. L. McGeer, E. G. McGeer

Istituto Oncologico Candiolo

Research output: Contribution to journal › Article › peer-review

Abstract

Hepatocyte growth factor (HGF) is a potent mitogen for mature hepatocytes, and also has multifunctional effects on some other cells in various organs. The human c-Met proto-oncogene product has recently been identified as its high-affinity receptor. We examined HGF-like and c-Met protein-like immunoreactivities in the brains of neurologically normal, lacunar stroke and Alzheimer disease (AD) cases. The HGF antibody stained only round cells in the capillaries and astrocytes in the white matter. Positive staining with the antibody to c-Met protein was seen in microglia, predominantly in the white matter. The possibility of interactions between astrocytes and microglia through HGF and its receptor is suggested.

Original language	English
Pages (from-to)	308-312
Number of pages	5
Journal	Brain Research
Volume	637
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(94)91250-5
Publication status	Published - Feb 21 1994

Keywords

Alzheimer's disease
Astrocyte
c-Met protein
Hepatocytes growth factor
Microglia

ASJC Scopus subject areas

Developmental Biology
Molecular Biology
Clinical Neurology
Neuroscience(all)

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title = "Immunohistochemistry with antibodies to hepatocyte growth factor and its receptor protein (c-MET) in human brain tissues",

abstract = "Hepatocyte growth factor (HGF) is a potent mitogen for mature hepatocytes, and also has multifunctional effects on some other cells in various organs. The human c-Met proto-oncogene product has recently been identified as its high-affinity receptor. We examined HGF-like and c-Met protein-like immunoreactivities in the brains of neurologically normal, lacunar stroke and Alzheimer disease (AD) cases. The HGF antibody stained only round cells in the capillaries and astrocytes in the white matter. Positive staining with the antibody to c-Met protein was seen in microglia, predominantly in the white matter. The possibility of interactions between astrocytes and microglia through HGF and its receptor is suggested.",

keywords = "Alzheimer's disease, Astrocyte, c-Met protein, Hepatocytes growth factor, Microglia",

author = "T. Yamada and H. Tsubouchi and Y. Daikuhara and M. Prat and Comoglio, {P. M.} and McGeer, {P. L.} and McGeer, {E. G.}",

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T1 - Immunohistochemistry with antibodies to hepatocyte growth factor and its receptor protein (c-MET) in human brain tissues

AU - Yamada, T.

AU - Tsubouchi, H.

AU - Daikuhara, Y.

AU - Prat, M.

AU - Comoglio, P. M.

AU - McGeer, P. L.

AU - McGeer, E. G.

PY - 1994/2/21

Y1 - 1994/2/21

N2 - Hepatocyte growth factor (HGF) is a potent mitogen for mature hepatocytes, and also has multifunctional effects on some other cells in various organs. The human c-Met proto-oncogene product has recently been identified as its high-affinity receptor. We examined HGF-like and c-Met protein-like immunoreactivities in the brains of neurologically normal, lacunar stroke and Alzheimer disease (AD) cases. The HGF antibody stained only round cells in the capillaries and astrocytes in the white matter. Positive staining with the antibody to c-Met protein was seen in microglia, predominantly in the white matter. The possibility of interactions between astrocytes and microglia through HGF and its receptor is suggested.

AB - Hepatocyte growth factor (HGF) is a potent mitogen for mature hepatocytes, and also has multifunctional effects on some other cells in various organs. The human c-Met proto-oncogene product has recently been identified as its high-affinity receptor. We examined HGF-like and c-Met protein-like immunoreactivities in the brains of neurologically normal, lacunar stroke and Alzheimer disease (AD) cases. The HGF antibody stained only round cells in the capillaries and astrocytes in the white matter. Positive staining with the antibody to c-Met protein was seen in microglia, predominantly in the white matter. The possibility of interactions between astrocytes and microglia through HGF and its receptor is suggested.

KW - Alzheimer's disease

KW - Astrocyte

KW - c-Met protein

KW - Hepatocytes growth factor

KW - Microglia

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