Immunohistological analysis of Rosai-Dorfman histiocytosis - A disease of S-100 + CD1-histiocytes

Franco Bonetti; Marco Chilosi; Fabio Menestrina; Aldo Scarpa; Pier Giuseppe Pelicci; Edward Amorosi; Luciano Fiore-Donati; Daniel M. Knowles

doi:10.1007/BF00712736

Immunohistological analysis of Rosai-Dorfman histiocytosis - A disease of S-100 + CD1-histiocytes

Franco Bonetti, Marco Chilosi, Fabio Menestrina, Aldo Scarpa, Pier Giuseppe Pelicci, Edward Amorosi, Luciano Fiore-Donati, Daniel M. Knowles

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

Five cases of Rosai-Dorfman histiocytosis (RDH) (also called Sinus Histiocytosis with Massive Lymphoadenopathy; SHML) have been studied by immunohistochemical methods with heteroantisera and monoclonal antibodies. One case was also studied by Southern blot hybridization analysis with DNA probes specific for T cell receptor beta chain and immunoglobulin heavy chain. Immunophenotyping of large histiocytes, characteristic of RDH, evidenced the presence of S-100 protein and the absence of CD1 and other markers usually found in histiocytes and macrophages. DNA hybridization study showed the absence of clonal T or B lymphoid populations.

Original language	English
Pages (from-to)	129-135
Number of pages	7
Journal	Virchows Archiv A Pathological Anatomy and Histopathology
Volume	411
Issue number	2
DOIs	https://doi.org/10.1007/BF00712736
Publication status	Published - Mar 1987

Keywords

Immunohistochemistry
Lymph node
Rosai-Dorfman histiocytosis

ASJC Scopus subject areas

Pathology and Forensic Medicine
Anatomy

Access to Document

10.1007/BF00712736

Cite this

@article{dc0abb37492e46e4a2507b6d14c165b9,

title = "Immunohistological analysis of Rosai-Dorfman histiocytosis - A disease of S-100 + CD1-histiocytes",

abstract = "Five cases of Rosai-Dorfman histiocytosis (RDH) (also called Sinus Histiocytosis with Massive Lymphoadenopathy; SHML) have been studied by immunohistochemical methods with heteroantisera and monoclonal antibodies. One case was also studied by Southern blot hybridization analysis with DNA probes specific for T cell receptor beta chain and immunoglobulin heavy chain. Immunophenotyping of large histiocytes, characteristic of RDH, evidenced the presence of S-100 protein and the absence of CD1 and other markers usually found in histiocytes and macrophages. DNA hybridization study showed the absence of clonal T or B lymphoid populations.",

keywords = "Immunohistochemistry, Lymph node, Rosai-Dorfman histiocytosis",

author = "Franco Bonetti and Marco Chilosi and Fabio Menestrina and Aldo Scarpa and Pelicci, {Pier Giuseppe} and Edward Amorosi and Luciano Fiore-Donati and Knowles, {Daniel M.}",

year = "1987",

month = mar,

doi = "10.1007/BF00712736",

language = "English",

volume = "411",

pages = "129--135",

journal = "Virchows Archiv - A Pathological Anatomy and Histopathology",

issn = "0945-6317",

publisher = "Springer Verlag",

number = "2",

}

TY - JOUR

T1 - Immunohistological analysis of Rosai-Dorfman histiocytosis - A disease of S-100 + CD1-histiocytes

AU - Bonetti, Franco

AU - Chilosi, Marco

AU - Menestrina, Fabio

AU - Scarpa, Aldo

AU - Pelicci, Pier Giuseppe

AU - Amorosi, Edward

AU - Fiore-Donati, Luciano

AU - Knowles, Daniel M.

PY - 1987/3

Y1 - 1987/3

N2 - Five cases of Rosai-Dorfman histiocytosis (RDH) (also called Sinus Histiocytosis with Massive Lymphoadenopathy; SHML) have been studied by immunohistochemical methods with heteroantisera and monoclonal antibodies. One case was also studied by Southern blot hybridization analysis with DNA probes specific for T cell receptor beta chain and immunoglobulin heavy chain. Immunophenotyping of large histiocytes, characteristic of RDH, evidenced the presence of S-100 protein and the absence of CD1 and other markers usually found in histiocytes and macrophages. DNA hybridization study showed the absence of clonal T or B lymphoid populations.

AB - Five cases of Rosai-Dorfman histiocytosis (RDH) (also called Sinus Histiocytosis with Massive Lymphoadenopathy; SHML) have been studied by immunohistochemical methods with heteroantisera and monoclonal antibodies. One case was also studied by Southern blot hybridization analysis with DNA probes specific for T cell receptor beta chain and immunoglobulin heavy chain. Immunophenotyping of large histiocytes, characteristic of RDH, evidenced the presence of S-100 protein and the absence of CD1 and other markers usually found in histiocytes and macrophages. DNA hybridization study showed the absence of clonal T or B lymphoid populations.

KW - Immunohistochemistry

KW - Lymph node

KW - Rosai-Dorfman histiocytosis

UR - http://www.scopus.com/inward/record.url?scp=0023216942&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023216942&partnerID=8YFLogxK

U2 - 10.1007/BF00712736

DO - 10.1007/BF00712736

M3 - Article

C2 - 3111077

AN - SCOPUS:0023216942

VL - 411

SP - 129

EP - 135

JO - Virchows Archiv - A Pathological Anatomy and Histopathology

JF - Virchows Archiv - A Pathological Anatomy and Histopathology

SN - 0945-6317

IS - 2

ER -

Immunohistological analysis of Rosai-Dorfman histiocytosis - A disease of S-100 + CD1-histiocytes

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this