Five cases of Rosai-Dorfman histiocytosis (RDH) (also called Sinus Histiocytosis with Massive Lymphoadenopathy; SHML) have been studied by immunohistochemical methods with heteroantisera and monoclonal antibodies. One case was also studied by Southern blot hybridization analysis with DNA probes specific for T cell receptor beta chain and immunoglobulin heavy chain. Immunophenotyping of large histiocytes, characteristic of RDH, evidenced the presence of S-100 protein and the absence of CD1 and other markers usually found in histiocytes and macrophages. DNA hybridization study showed the absence of clonal T or B lymphoid populations.
|Number of pages||7|
|Journal||Virchows Archiv A Pathological Anatomy and Histopathology|
|Publication status||Published - Mar 1987|
- Lymph node
- Rosai-Dorfman histiocytosis
ASJC Scopus subject areas
- Pathology and Forensic Medicine