TY - JOUR
T1 - Immunohistological analysis of Rosai-Dorfman histiocytosis - A disease of S-100 + CD1-histiocytes
AU - Bonetti, Franco
AU - Chilosi, Marco
AU - Menestrina, Fabio
AU - Scarpa, Aldo
AU - Pelicci, Pier Giuseppe
AU - Amorosi, Edward
AU - Fiore-Donati, Luciano
AU - Knowles, Daniel M.
PY - 1987/3
Y1 - 1987/3
N2 - Five cases of Rosai-Dorfman histiocytosis (RDH) (also called Sinus Histiocytosis with Massive Lymphoadenopathy; SHML) have been studied by immunohistochemical methods with heteroantisera and monoclonal antibodies. One case was also studied by Southern blot hybridization analysis with DNA probes specific for T cell receptor beta chain and immunoglobulin heavy chain. Immunophenotyping of large histiocytes, characteristic of RDH, evidenced the presence of S-100 protein and the absence of CD1 and other markers usually found in histiocytes and macrophages. DNA hybridization study showed the absence of clonal T or B lymphoid populations.
AB - Five cases of Rosai-Dorfman histiocytosis (RDH) (also called Sinus Histiocytosis with Massive Lymphoadenopathy; SHML) have been studied by immunohistochemical methods with heteroantisera and monoclonal antibodies. One case was also studied by Southern blot hybridization analysis with DNA probes specific for T cell receptor beta chain and immunoglobulin heavy chain. Immunophenotyping of large histiocytes, characteristic of RDH, evidenced the presence of S-100 protein and the absence of CD1 and other markers usually found in histiocytes and macrophages. DNA hybridization study showed the absence of clonal T or B lymphoid populations.
KW - Immunohistochemistry
KW - Lymph node
KW - Rosai-Dorfman histiocytosis
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U2 - 10.1007/BF00712736
DO - 10.1007/BF00712736
M3 - Article
C2 - 3111077
AN - SCOPUS:0023216942
VL - 411
SP - 129
EP - 135
JO - Virchows Archiv - A Pathological Anatomy and Histopathology
JF - Virchows Archiv - A Pathological Anatomy and Histopathology
SN - 0945-6317
IS - 2
ER -