Immunohistological analysis of Rosai-Dorfman histiocytosis - A disease of S-100 + CD1-histiocytes

Franco Bonetti, Marco Chilosi, Fabio Menestrina, Aldo Scarpa, Pier Giuseppe Pelicci, Edward Amorosi, Luciano Fiore-Donati, Daniel M. Knowles

Research output: Contribution to journalArticlepeer-review


Five cases of Rosai-Dorfman histiocytosis (RDH) (also called Sinus Histiocytosis with Massive Lymphoadenopathy; SHML) have been studied by immunohistochemical methods with heteroantisera and monoclonal antibodies. One case was also studied by Southern blot hybridization analysis with DNA probes specific for T cell receptor beta chain and immunoglobulin heavy chain. Immunophenotyping of large histiocytes, characteristic of RDH, evidenced the presence of S-100 protein and the absence of CD1 and other markers usually found in histiocytes and macrophages. DNA hybridization study showed the absence of clonal T or B lymphoid populations.

Original languageEnglish
Pages (from-to)129-135
Number of pages7
JournalVirchows Archiv A Pathological Anatomy and Histopathology
Issue number2
Publication statusPublished - Mar 1987


  • Immunohistochemistry
  • Lymph node
  • Rosai-Dorfman histiocytosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Anatomy


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