Immunohistological analysis of Rosai-Dorfman histiocytosis - A disease of S-100 + CD1-histiocytes

Franco Bonetti; Marco Chilosi; Fabio Menestrina; Aldo Scarpa; Pier Giuseppe Pelicci; Edward Amorosi; Luciano Fiore-Donati; Daniel M. Knowles

doi:10.1007/BF00712736

Immunohistological analysis of Rosai-Dorfman histiocytosis - A disease of S-100 + CD1-histiocytes

Franco Bonetti, Marco Chilosi, Fabio Menestrina, Aldo Scarpa, Pier Giuseppe Pelicci, Edward Amorosi, Luciano Fiore-Donati, Daniel M. Knowles

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

Five cases of Rosai-Dorfman histiocytosis (RDH) (also called Sinus Histiocytosis with Massive Lymphoadenopathy; SHML) have been studied by immunohistochemical methods with heteroantisera and monoclonal antibodies. One case was also studied by Southern blot hybridization analysis with DNA probes specific for T cell receptor beta chain and immunoglobulin heavy chain. Immunophenotyping of large histiocytes, characteristic of RDH, evidenced the presence of S-100 protein and the absence of CD1 and other markers usually found in histiocytes and macrophages. DNA hybridization study showed the absence of clonal T or B lymphoid populations.

Original language	English
Pages (from-to)	129-135
Number of pages	7
Journal	Virchows Archiv A Pathological Anatomy and Histopathology
Volume	411
Issue number	2
DOIs	https://doi.org/10.1007/BF00712736
Publication status	Published - Mar 1987

Keywords

Immunohistochemistry
Lymph node
Rosai-Dorfman histiocytosis

ASJC Scopus subject areas

Pathology and Forensic Medicine
Anatomy

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10.1007/BF00712736

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Immunohistological analysis of Rosai-Dorfman histiocytosis - A disease of S-100 + CD1-histiocytes. / Bonetti, Franco; Chilosi, Marco; Menestrina, Fabio; Scarpa, Aldo; Pelicci, Pier Giuseppe; Amorosi, Edward; Fiore-Donati, Luciano; Knowles, Daniel M.

In: Virchows Archiv A Pathological Anatomy and Histopathology, Vol. 411, No. 2, 03.1987, p. 129-135.

Research output: Contribution to journal › Article › peer-review

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abstract = "Five cases of Rosai-Dorfman histiocytosis (RDH) (also called Sinus Histiocytosis with Massive Lymphoadenopathy; SHML) have been studied by immunohistochemical methods with heteroantisera and monoclonal antibodies. One case was also studied by Southern blot hybridization analysis with DNA probes specific for T cell receptor beta chain and immunoglobulin heavy chain. Immunophenotyping of large histiocytes, characteristic of RDH, evidenced the presence of S-100 protein and the absence of CD1 and other markers usually found in histiocytes and macrophages. DNA hybridization study showed the absence of clonal T or B lymphoid populations.",

keywords = "Immunohistochemistry, Lymph node, Rosai-Dorfman histiocytosis",

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AU - Bonetti, Franco

AU - Chilosi, Marco

AU - Menestrina, Fabio

AU - Scarpa, Aldo

AU - Pelicci, Pier Giuseppe

AU - Amorosi, Edward

AU - Fiore-Donati, Luciano

AU - Knowles, Daniel M.

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N2 - Five cases of Rosai-Dorfman histiocytosis (RDH) (also called Sinus Histiocytosis with Massive Lymphoadenopathy; SHML) have been studied by immunohistochemical methods with heteroantisera and monoclonal antibodies. One case was also studied by Southern blot hybridization analysis with DNA probes specific for T cell receptor beta chain and immunoglobulin heavy chain. Immunophenotyping of large histiocytes, characteristic of RDH, evidenced the presence of S-100 protein and the absence of CD1 and other markers usually found in histiocytes and macrophages. DNA hybridization study showed the absence of clonal T or B lymphoid populations.

AB - Five cases of Rosai-Dorfman histiocytosis (RDH) (also called Sinus Histiocytosis with Massive Lymphoadenopathy; SHML) have been studied by immunohistochemical methods with heteroantisera and monoclonal antibodies. One case was also studied by Southern blot hybridization analysis with DNA probes specific for T cell receptor beta chain and immunoglobulin heavy chain. Immunophenotyping of large histiocytes, characteristic of RDH, evidenced the presence of S-100 protein and the absence of CD1 and other markers usually found in histiocytes and macrophages. DNA hybridization study showed the absence of clonal T or B lymphoid populations.

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Immunohistological analysis of Rosai-Dorfman histiocytosis - A disease of S-100 + CD1-histiocytes

Abstract

Keywords

ASJC Scopus subject areas

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