TY - JOUR
T1 - Immunohistological analysis of Tac antigen expression in tissues involved by Hodgkin's disease
AU - Pizzolo, G.
AU - Chilosi, M.
AU - Semenzato, G.
AU - Caligaris-Cappio, F.
AU - Fiore-Donati, L.
AU - Perona, G.
AU - Janossy, G.
PY - 1984
Y1 - 1984
N2 - The findings have at least two possible interpretations. First, anti-Tac may cross-react with epitopes on molecules other than IL-2 receptor. In that case the Tac positivity on H and RS cells could be only a useful identity marker. However, this possibility may not be the entire answer since in hairy cell leukaemia the molecular weight of the recognized Tac+ molecule is identical to that of the Tac receptor present on the IL-2 response cell lines (Korsmeyer et al., 1983). The more exciting possibility is therefore that Tac positivity on H and RS cells, as well as in hairy cell leukaemia and in other malignant conditions, might be a sign of the abnormal gene expression which may contribute to the uncontrolled growth or to the destructive influence seen in HD.
AB - The findings have at least two possible interpretations. First, anti-Tac may cross-react with epitopes on molecules other than IL-2 receptor. In that case the Tac positivity on H and RS cells could be only a useful identity marker. However, this possibility may not be the entire answer since in hairy cell leukaemia the molecular weight of the recognized Tac+ molecule is identical to that of the Tac receptor present on the IL-2 response cell lines (Korsmeyer et al., 1983). The more exciting possibility is therefore that Tac positivity on H and RS cells, as well as in hairy cell leukaemia and in other malignant conditions, might be a sign of the abnormal gene expression which may contribute to the uncontrolled growth or to the destructive influence seen in HD.
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U2 - 10.1038/bjc.1984.191
DO - 10.1038/bjc.1984.191
M3 - Article
C2 - 6087871
AN - SCOPUS:0021637665
VL - 50
SP - 415
EP - 417
JO - British Journal of Cancer
JF - British Journal of Cancer
SN - 0007-0920
IS - 3
ER -