Immunohistological characterization of lymph nodes in two cases of adult onset Still's disease

F. Quaini, P. Manganelli, S. Pileri, G. Magnani, C. Ferrari, R. Delsignore, E. Sabattini, G. Olivetti

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Although lymphadenopathy occurs in 60% of patients with adult Still's disease, its histopathological pattern has only recently been described. We report on the immunohistological study of a lymph node biopsy and the clinical course of 2 patients with adult Still's disease. The lymph node histology was characterized by a diffuse paracortical expansion with a high content of immunoblasts and plump endothelium venules. Immunohistochemistry using the alkaline phosphatase, antialkaline phosphatase technique showed the mixed B and T cell nature both of proliferating cells and immunoblasts. When antiheavy and light chain reagents were applied, the B cell component became polytypic. Our report stresses the relevance of immunohistological investigation in the diagnostic approach to Still's disease in which histological findings, if taken alone, might be misleading.

Original languageEnglish
Pages (from-to)1418-1423
Number of pages6
JournalJournal of Rheumatology
Volume18
Issue number9
Publication statusPublished - 1991

Fingerprint

Adult-Onset Still's Disease
Lymph Nodes
B-Lymphocytes
Venules
Cellular Structures
Phosphoric Monoester Hydrolases
Endothelium
Alkaline Phosphatase
Histology
Immunohistochemistry
T-Lymphocytes
Biopsy
Light

Keywords

  • Adult still's disease
  • Immunohistochemistry
  • Lymphadenopathy

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Quaini, F., Manganelli, P., Pileri, S., Magnani, G., Ferrari, C., Delsignore, R., ... Olivetti, G. (1991). Immunohistological characterization of lymph nodes in two cases of adult onset Still's disease. Journal of Rheumatology, 18(9), 1418-1423.

Immunohistological characterization of lymph nodes in two cases of adult onset Still's disease. / Quaini, F.; Manganelli, P.; Pileri, S.; Magnani, G.; Ferrari, C.; Delsignore, R.; Sabattini, E.; Olivetti, G.

In: Journal of Rheumatology, Vol. 18, No. 9, 1991, p. 1418-1423.

Research output: Contribution to journalArticle

Quaini, F, Manganelli, P, Pileri, S, Magnani, G, Ferrari, C, Delsignore, R, Sabattini, E & Olivetti, G 1991, 'Immunohistological characterization of lymph nodes in two cases of adult onset Still's disease', Journal of Rheumatology, vol. 18, no. 9, pp. 1418-1423.
Quaini F, Manganelli P, Pileri S, Magnani G, Ferrari C, Delsignore R et al. Immunohistological characterization of lymph nodes in two cases of adult onset Still's disease. Journal of Rheumatology. 1991;18(9):1418-1423.
Quaini, F. ; Manganelli, P. ; Pileri, S. ; Magnani, G. ; Ferrari, C. ; Delsignore, R. ; Sabattini, E. ; Olivetti, G. / Immunohistological characterization of lymph nodes in two cases of adult onset Still's disease. In: Journal of Rheumatology. 1991 ; Vol. 18, No. 9. pp. 1418-1423.
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