Abstract
Although lymphadenopathy occurs in 60% of patients with adult Still's disease, its histopathological pattern has only recently been described. We report on the immunohistological study of a lymph node biopsy and the clinical course of 2 patients with adult Still's disease. The lymph node histology was characterized by a diffuse paracortical expansion with a high content of immunoblasts and plump endothelium venules. Immunohistochemistry using the alkaline phosphatase, antialkaline phosphatase technique showed the mixed B and T cell nature both of proliferating cells and immunoblasts. When antiheavy and light chain reagents were applied, the B cell component became polytypic. Our report stresses the relevance of immunohistological investigation in the diagnostic approach to Still's disease in which histological findings, if taken alone, might be misleading.
| Original language | English |
|---|---|
| Pages (from-to) | 1418-1423 |
| Number of pages | 6 |
| Journal | Journal of Rheumatology |
| Volume | 18 |
| Issue number | 9 |
| Publication status | Published - 1991 |
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Keywords
- Adult still's disease
- Immunohistochemistry
- Lymphadenopathy
ASJC Scopus subject areas
- Immunology
- Rheumatology
Cite this
Immunohistological characterization of lymph nodes in two cases of adult onset Still's disease. / Quaini, F.; Manganelli, P.; Pileri, S.; Magnani, G.; Ferrari, C.; Delsignore, R.; Sabattini, E.; Olivetti, G.
In: Journal of Rheumatology, Vol. 18, No. 9, 1991, p. 1418-1423.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunohistological characterization of lymph nodes in two cases of adult onset Still's disease
AU - Quaini, F.
AU - Manganelli, P.
AU - Pileri, S.
AU - Magnani, G.
AU - Ferrari, C.
AU - Delsignore, R.
AU - Sabattini, E.
AU - Olivetti, G.
PY - 1991
Y1 - 1991
N2 - Although lymphadenopathy occurs in 60% of patients with adult Still's disease, its histopathological pattern has only recently been described. We report on the immunohistological study of a lymph node biopsy and the clinical course of 2 patients with adult Still's disease. The lymph node histology was characterized by a diffuse paracortical expansion with a high content of immunoblasts and plump endothelium venules. Immunohistochemistry using the alkaline phosphatase, antialkaline phosphatase technique showed the mixed B and T cell nature both of proliferating cells and immunoblasts. When antiheavy and light chain reagents were applied, the B cell component became polytypic. Our report stresses the relevance of immunohistological investigation in the diagnostic approach to Still's disease in which histological findings, if taken alone, might be misleading.
AB - Although lymphadenopathy occurs in 60% of patients with adult Still's disease, its histopathological pattern has only recently been described. We report on the immunohistological study of a lymph node biopsy and the clinical course of 2 patients with adult Still's disease. The lymph node histology was characterized by a diffuse paracortical expansion with a high content of immunoblasts and plump endothelium venules. Immunohistochemistry using the alkaline phosphatase, antialkaline phosphatase technique showed the mixed B and T cell nature both of proliferating cells and immunoblasts. When antiheavy and light chain reagents were applied, the B cell component became polytypic. Our report stresses the relevance of immunohistological investigation in the diagnostic approach to Still's disease in which histological findings, if taken alone, might be misleading.
KW - Adult still's disease
KW - Immunohistochemistry
KW - Lymphadenopathy
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UR - http://www.scopus.com/inward/citedby.url?scp=0025989741&partnerID=8YFLogxK
M3 - Article
VL - 18
SP - 1418
EP - 1423
JO - Journal of Rheumatology
JF - Journal of Rheumatology
SN - 0315-162X
IS - 9
ER -