TY - JOUR
T1 - Immunohistological characterization of lymph nodes in two cases of adult onset Still's disease
AU - Quaini, F.
AU - Manganelli, P.
AU - Pileri, S.
AU - Magnani, G.
AU - Ferrari, C.
AU - Delsignore, R.
AU - Sabattini, E.
AU - Olivetti, G.
PY - 1991
Y1 - 1991
N2 - Although lymphadenopathy occurs in 60% of patients with adult Still's disease, its histopathological pattern has only recently been described. We report on the immunohistological study of a lymph node biopsy and the clinical course of 2 patients with adult Still's disease. The lymph node histology was characterized by a diffuse paracortical expansion with a high content of immunoblasts and plump endothelium venules. Immunohistochemistry using the alkaline phosphatase, antialkaline phosphatase technique showed the mixed B and T cell nature both of proliferating cells and immunoblasts. When antiheavy and light chain reagents were applied, the B cell component became polytypic. Our report stresses the relevance of immunohistological investigation in the diagnostic approach to Still's disease in which histological findings, if taken alone, might be misleading.
AB - Although lymphadenopathy occurs in 60% of patients with adult Still's disease, its histopathological pattern has only recently been described. We report on the immunohistological study of a lymph node biopsy and the clinical course of 2 patients with adult Still's disease. The lymph node histology was characterized by a diffuse paracortical expansion with a high content of immunoblasts and plump endothelium venules. Immunohistochemistry using the alkaline phosphatase, antialkaline phosphatase technique showed the mixed B and T cell nature both of proliferating cells and immunoblasts. When antiheavy and light chain reagents were applied, the B cell component became polytypic. Our report stresses the relevance of immunohistological investigation in the diagnostic approach to Still's disease in which histological findings, if taken alone, might be misleading.
KW - Adult still's disease
KW - Immunohistochemistry
KW - Lymphadenopathy
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M3 - Article
C2 - 1757949
AN - SCOPUS:0025989741
VL - 18
SP - 1418
EP - 1423
JO - Journal of Rheumatology
JF - Journal of Rheumatology
SN - 0315-162X
IS - 9
ER -