Immunohistological characterization of lymph nodes in two cases of adult onset Still's disease

F. Quaini, P. Manganelli, S. Pileri, G. Magnani, C. Ferrari, R. Delsignore, E. Sabattini, G. Olivetti

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Although lymphadenopathy occurs in 60% of patients with adult Still's disease, its histopathological pattern has only recently been described. We report on the immunohistological study of a lymph node biopsy and the clinical course of 2 patients with adult Still's disease. The lymph node histology was characterized by a diffuse paracortical expansion with a high content of immunoblasts and plump endothelium venules. Immunohistochemistry using the alkaline phosphatase, antialkaline phosphatase technique showed the mixed B and T cell nature both of proliferating cells and immunoblasts. When antiheavy and light chain reagents were applied, the B cell component became polytypic. Our report stresses the relevance of immunohistological investigation in the diagnostic approach to Still's disease in which histological findings, if taken alone, might be misleading.

Original languageEnglish
Pages (from-to)1418-1423
Number of pages6
JournalJournal of Rheumatology
Issue number9
Publication statusPublished - 1991


  • Adult still's disease
  • Immunohistochemistry
  • Lymphadenopathy

ASJC Scopus subject areas

  • Immunology
  • Rheumatology


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