Immunolocalization of sperm protein 17 in human testis and ejaculated spermatozoa

Fabio Grizzi, Maurizio Chiriva-Internati, Barbara Franceschini, Paul L. Hermonat, Giuseppe Soda, Seah H. Lim, Nicola Dioguardi

Research output: Contribution to journalArticlepeer-review


Sperm protein 17(Sp17) is a highly conserved mammalian protein whose primary function is still poorly understood. Immunohistochemistry (IHC) in the human testis reveals the presence of Sp17 in some spermatocytes and abundantly in spermatids. All spermatogonia, Sertoli cells, and Leydig cells appear to be immunonegative for Sp17, whereas some interstitial cells are immunopositive. IHC recognized two distinct populations (immunopositive or not for Sp17) in the ejaculated spermatozoa. Although it will be necessary to clarify why some ejaculated spermatozoa do not contain Sp17, its distribution suggests that this protein may be associated with some phases of germinal cell differentiation.

Original languageEnglish
Pages (from-to)1245-1248
Number of pages4
JournalJournal of Histochemistry and Cytochemistry
Issue number9
Publication statusPublished - Sep 1 2003


  • Immunohistochemistry
  • Sperm protein 17
  • Spermatogenesis
  • Testis

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology


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