TY - JOUR
T1 - Immunolocalization of sperm protein 17 in human testis and ejaculated spermatozoa
AU - Grizzi, Fabio
AU - Chiriva-Internati, Maurizio
AU - Franceschini, Barbara
AU - Hermonat, Paul L.
AU - Soda, Giuseppe
AU - Lim, Seah H.
AU - Dioguardi, Nicola
PY - 2003/9/1
Y1 - 2003/9/1
N2 - Sperm protein 17(Sp17) is a highly conserved mammalian protein whose primary function is still poorly understood. Immunohistochemistry (IHC) in the human testis reveals the presence of Sp17 in some spermatocytes and abundantly in spermatids. All spermatogonia, Sertoli cells, and Leydig cells appear to be immunonegative for Sp17, whereas some interstitial cells are immunopositive. IHC recognized two distinct populations (immunopositive or not for Sp17) in the ejaculated spermatozoa. Although it will be necessary to clarify why some ejaculated spermatozoa do not contain Sp17, its distribution suggests that this protein may be associated with some phases of germinal cell differentiation.
AB - Sperm protein 17(Sp17) is a highly conserved mammalian protein whose primary function is still poorly understood. Immunohistochemistry (IHC) in the human testis reveals the presence of Sp17 in some spermatocytes and abundantly in spermatids. All spermatogonia, Sertoli cells, and Leydig cells appear to be immunonegative for Sp17, whereas some interstitial cells are immunopositive. IHC recognized two distinct populations (immunopositive or not for Sp17) in the ejaculated spermatozoa. Although it will be necessary to clarify why some ejaculated spermatozoa do not contain Sp17, its distribution suggests that this protein may be associated with some phases of germinal cell differentiation.
KW - Immunohistochemistry
KW - Sperm protein 17
KW - Spermatogenesis
KW - Testis
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M3 - Article
C2 - 12923251
AN - SCOPUS:0041819761
VL - 51
SP - 1245
EP - 1248
JO - Journal of Histochemistry and Cytochemistry
JF - Journal of Histochemistry and Cytochemistry
SN - 0022-1554
IS - 9
ER -