Immunologic abnormalities in angioimmunoblastic lymphadenopathy

G. Pizzolo, F. Vinante, C. Agostini, R. Zambello, L. Trentin, M. Masciarelli, M. Chilosi, F. Benedetti, F. Dazzi, G. Todeschini, A. De Rossi, G. Semenzato

Research output: Contribution to journalArticle

Abstract

In this study we describe the results of phenotypic, serologic, and functional analyses performed in nine patients with angioimmunoblastic lymphadenopathy (AILD). The study investigates the nature of the T-cell defects which seem to represent a consistent feature in this disease. The study, based on the analysis of T-cell subsets with monoclonal antibodies and on functional in vitro tests, showed the following main abnormalities: reduction of the absolute number of circulating T-cells; inversion of the CD4/CD8 ratio, both in the peripheral blood and in the involved lymph nodes; high percentages of activated T-cells (CD8+/HLA-DR+); defective T-cell response in vitro to the PHA mitogen; and minimal helper and enhanced in vitro suppressor functions. Some of these immunologic dysfunctions are also observed in acquired immune deficiency syndrome (AIDS) which has in common with AILD several clinical features. However, no evidence of HTLV-III infection could be demonstrated in our patients with AILD.

Original languageEnglish
Pages (from-to)2412-2418
Number of pages7
JournalCancer
Volume60
Issue number10
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Pizzolo, G., Vinante, F., Agostini, C., Zambello, R., Trentin, L., Masciarelli, M., Chilosi, M., Benedetti, F., Dazzi, F., Todeschini, G., De Rossi, A., & Semenzato, G. (1987). Immunologic abnormalities in angioimmunoblastic lymphadenopathy. Cancer, 60(10), 2412-2418.