Immunologic abnormalities related to antigenaemia during HIV-1 infection

P. De Paoli, S. Battistin, M. Crovatto, M. L. Modolo, A. Carbone, U. Tirelli, G. Santini

Research output: Contribution to journalArticle

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Abstract

The expression of phenotypic markers on T and B lymphocytes in long-term human immunodeficiency virus type 1 (HIV-1) seropositive, antigen negative patients, in seropositive, antigen positive individuals without AIDS and in seronegative intravenous drug abusers was examined by two colour flow cytometry. Seropositive, antigen positive patients showed decreased CD4+ lymphocyte numbers, causing lower CD4/CD8 ratios when compared to seropositive, antigen negative subjects. While CD4 CDw29+ (4B4) lymphocytes are selectively reduced in seropositive, antigen negative individuals, both CD4 CDw29+ and CD4 CD45R+ (2H4) lymphocytes are decreased when antigenaemia is present. An increased percentage of CD3 HLA DR+ activated T lymphocytes and of CD20+ (B1) Leu 8 negative activated B cells was seen in HIV-1 seropositive antigen positive patients. These results demonstrate that, in long-term seropositive individuals, antigenaemia is associated with peculiar phenotypic changes of lymphocyte subsets.

Original languageEnglish
Pages (from-to)317-320
Number of pages4
JournalClinical and Experimental Immunology
Volume74
Issue number3
Publication statusPublished - 1988

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Virus Diseases
HIV-1
Antigens
B-Lymphocytes
Lymphocytes
T-Lymphocytes
CD4-CD8 Ratio
Lymphocyte Subsets
Lymphocyte Count
HLA-DR Antigens
Drug Users
Flow Cytometry
Acquired Immunodeficiency Syndrome
Color

ASJC Scopus subject areas

  • Immunology

Cite this

De Paoli, P., Battistin, S., Crovatto, M., Modolo, M. L., Carbone, A., Tirelli, U., & Santini, G. (1988). Immunologic abnormalities related to antigenaemia during HIV-1 infection. Clinical and Experimental Immunology, 74(3), 317-320.

Immunologic abnormalities related to antigenaemia during HIV-1 infection. / De Paoli, P.; Battistin, S.; Crovatto, M.; Modolo, M. L.; Carbone, A.; Tirelli, U.; Santini, G.

In: Clinical and Experimental Immunology, Vol. 74, No. 3, 1988, p. 317-320.

Research output: Contribution to journalArticle

De Paoli, P, Battistin, S, Crovatto, M, Modolo, ML, Carbone, A, Tirelli, U & Santini, G 1988, 'Immunologic abnormalities related to antigenaemia during HIV-1 infection', Clinical and Experimental Immunology, vol. 74, no. 3, pp. 317-320.
De Paoli P, Battistin S, Crovatto M, Modolo ML, Carbone A, Tirelli U et al. Immunologic abnormalities related to antigenaemia during HIV-1 infection. Clinical and Experimental Immunology. 1988;74(3):317-320.
De Paoli, P. ; Battistin, S. ; Crovatto, M. ; Modolo, M. L. ; Carbone, A. ; Tirelli, U. ; Santini, G. / Immunologic abnormalities related to antigenaemia during HIV-1 infection. In: Clinical and Experimental Immunology. 1988 ; Vol. 74, No. 3. pp. 317-320.
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