Abstract
In order to establish if immunologic alterations seen in acquired immunodeficiency syndrome (AIDS)-associated Kaposi's sarcoma are also present in the primary form of this malignancy, peripheral blood T-lymphocyte characterization and HLA, A, B, C, and DR phenotyping have been carried out in 18 patients with the primary form of the disease. HLA antigen distribution was not significantly different from that of the normal population and, in particular, DR5 was only marginally increased. The T4/T8 ratio was significantly higher in the patients than in the control group, and this was due to a marked decrease in suppressor cells. The possible pathogenetic relevance of these findings is discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 1899-1901 |
| Number of pages | 3 |
| Journal | Cancer |
| Volume | 55 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 1985 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
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Immunologic and immunogenetic features of primary Kaposi's sarcoma. / Marinig, C.; Fiorini, G.; Boneschi, V.; Melotti, E.; Brambilla, L.
In: Cancer, Vol. 55, No. 9, 1985, p. 1899-1901.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunologic and immunogenetic features of primary Kaposi's sarcoma
AU - Marinig, C.
AU - Fiorini, G.
AU - Boneschi, V.
AU - Melotti, E.
AU - Brambilla, L.
PY - 1985
Y1 - 1985
N2 - In order to establish if immunologic alterations seen in acquired immunodeficiency syndrome (AIDS)-associated Kaposi's sarcoma are also present in the primary form of this malignancy, peripheral blood T-lymphocyte characterization and HLA, A, B, C, and DR phenotyping have been carried out in 18 patients with the primary form of the disease. HLA antigen distribution was not significantly different from that of the normal population and, in particular, DR5 was only marginally increased. The T4/T8 ratio was significantly higher in the patients than in the control group, and this was due to a marked decrease in suppressor cells. The possible pathogenetic relevance of these findings is discussed.
AB - In order to establish if immunologic alterations seen in acquired immunodeficiency syndrome (AIDS)-associated Kaposi's sarcoma are also present in the primary form of this malignancy, peripheral blood T-lymphocyte characterization and HLA, A, B, C, and DR phenotyping have been carried out in 18 patients with the primary form of the disease. HLA antigen distribution was not significantly different from that of the normal population and, in particular, DR5 was only marginally increased. The T4/T8 ratio was significantly higher in the patients than in the control group, and this was due to a marked decrease in suppressor cells. The possible pathogenetic relevance of these findings is discussed.
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UR - http://www.scopus.com/inward/citedby.url?scp=0022002914&partnerID=8YFLogxK
U2 - 10.1002/1097-0142(19850501)55:9<1899::AID-CNCR2820550911>3.0.CO;2-D
DO - 10.1002/1097-0142(19850501)55:9<1899::AID-CNCR2820550911>3.0.CO;2-D
M3 - Article
C2 - 3156665
AN - SCOPUS:0022002914
VL - 55
SP - 1899
EP - 1901
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 9
ER -