Immunologic and immunogenetic features of primary Kaposi's sarcoma

C. Marinig, G. Fiorini, V. Boneschi, E. Melotti, L. Brambilla

Research output: Contribution to journalArticle

Abstract

In order to establish if immunologic alterations seen in acquired immunodeficiency syndrome (AIDS)-associated Kaposi's sarcoma are also present in the primary form of this malignancy, peripheral blood T-lymphocyte characterization and HLA, A, B, C, and DR phenotyping have been carried out in 18 patients with the primary form of the disease. HLA antigen distribution was not significantly different from that of the normal population and, in particular, DR5 was only marginally increased. The T4/T8 ratio was significantly higher in the patients than in the control group, and this was due to a marked decrease in suppressor cells. The possible pathogenetic relevance of these findings is discussed.

Original languageEnglish
Pages (from-to)1899-1901
Number of pages3
JournalCancer
Volume55
Issue number9
DOIs
Publication statusPublished - 1985

Fingerprint

Immunogenetics
Kaposi's Sarcoma
CD4-CD8 Ratio
HLA-A Antigens
HLA-B Antigens
HLA Antigens
Acquired Immunodeficiency Syndrome
T-Lymphocytes
Control Groups
Population
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Immunologic and immunogenetic features of primary Kaposi's sarcoma. / Marinig, C.; Fiorini, G.; Boneschi, V.; Melotti, E.; Brambilla, L.

In: Cancer, Vol. 55, No. 9, 1985, p. 1899-1901.

Research output: Contribution to journalArticle

Marinig, C. ; Fiorini, G. ; Boneschi, V. ; Melotti, E. ; Brambilla, L. / Immunologic and immunogenetic features of primary Kaposi's sarcoma. In: Cancer. 1985 ; Vol. 55, No. 9. pp. 1899-1901.
@article{ab3979daa68c426d940a0bfce69c4304,
title = "Immunologic and immunogenetic features of primary Kaposi's sarcoma",
abstract = "In order to establish if immunologic alterations seen in acquired immunodeficiency syndrome (AIDS)-associated Kaposi's sarcoma are also present in the primary form of this malignancy, peripheral blood T-lymphocyte characterization and HLA, A, B, C, and DR phenotyping have been carried out in 18 patients with the primary form of the disease. HLA antigen distribution was not significantly different from that of the normal population and, in particular, DR5 was only marginally increased. The T4/T8 ratio was significantly higher in the patients than in the control group, and this was due to a marked decrease in suppressor cells. The possible pathogenetic relevance of these findings is discussed.",
author = "C. Marinig and G. Fiorini and V. Boneschi and E. Melotti and L. Brambilla",
year = "1985",
doi = "10.1002/1097-0142(19850501)55:9<1899::AID-CNCR2820550911>3.0.CO;2-D",
language = "English",
volume = "55",
pages = "1899--1901",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "9",

}

TY - JOUR

T1 - Immunologic and immunogenetic features of primary Kaposi's sarcoma

AU - Marinig, C.

AU - Fiorini, G.

AU - Boneschi, V.

AU - Melotti, E.

AU - Brambilla, L.

PY - 1985

Y1 - 1985

N2 - In order to establish if immunologic alterations seen in acquired immunodeficiency syndrome (AIDS)-associated Kaposi's sarcoma are also present in the primary form of this malignancy, peripheral blood T-lymphocyte characterization and HLA, A, B, C, and DR phenotyping have been carried out in 18 patients with the primary form of the disease. HLA antigen distribution was not significantly different from that of the normal population and, in particular, DR5 was only marginally increased. The T4/T8 ratio was significantly higher in the patients than in the control group, and this was due to a marked decrease in suppressor cells. The possible pathogenetic relevance of these findings is discussed.

AB - In order to establish if immunologic alterations seen in acquired immunodeficiency syndrome (AIDS)-associated Kaposi's sarcoma are also present in the primary form of this malignancy, peripheral blood T-lymphocyte characterization and HLA, A, B, C, and DR phenotyping have been carried out in 18 patients with the primary form of the disease. HLA antigen distribution was not significantly different from that of the normal population and, in particular, DR5 was only marginally increased. The T4/T8 ratio was significantly higher in the patients than in the control group, and this was due to a marked decrease in suppressor cells. The possible pathogenetic relevance of these findings is discussed.

UR - http://www.scopus.com/inward/record.url?scp=0022002914&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022002914&partnerID=8YFLogxK

U2 - 10.1002/1097-0142(19850501)55:9<1899::AID-CNCR2820550911>3.0.CO;2-D

DO - 10.1002/1097-0142(19850501)55:9<1899::AID-CNCR2820550911>3.0.CO;2-D

M3 - Article

C2 - 3156665

AN - SCOPUS:0022002914

VL - 55

SP - 1899

EP - 1901

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 9

ER -